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fimA type 1 fimbriae major subunit [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948838, updated on 19-Sep-2024

Summary

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Official Symbol
fimA
Official Full Name
type 1 fimbriae major subunit
Primary source
ECOCYC:EG10308
Locus tag
b4314
See related
ASAP:ABE-0014145
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4305; fimD; pilA
Summary
One of 25 FimA homologs in EcoGene. [More information is available at EcoGene: EG10308]. FimA, the major subunit of the Escherichia coli type 1 fimbriae (pili) has been identified and its gene sequence determined , . [More information is available at EcoCyc: EG10308].
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Genomic context

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Sequence:
NC_000913.3 (4543115..4543663)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene Type 1 fimbriae regulatory protein FimB Neighboring gene regulator for fimA Neighboring gene putative fimbrial protein FimI Neighboring gene type 1 fimbriae periplasmic chaperone

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure, folding and stability of FimA, the main structural subunit of type 1 pili from uropathogenic Escherichia coli strains. Puorger C, et al. J Mol Biol, 2011 Sep 23. PMID 21816158
  2. Identification and characterization of a gene product that regulates type 1 piliation in Escherichia coli. Orndorff PE, et al. J Bacteriol, 1984 Oct. PMID 6148338, Free PMC Article
  3. Role of type 1 fimbriae and mannose in the development of Escherichia coli K12 biofilm: from initial cell adhesion to biofilm formation. Rodrigues DF, et al. Biofouling, 2009. PMID 19306144
  4. Glycerol-induced unraveling of the tight helical conformation of Escherichia coli type 1 fimbriae. Abraham SN, et al. J Bacteriol, 1992 Aug. PMID 1352770, Free PMC Article
  5. F7 and type 1-like fimbriae from three Escherichia coli strains isolated from urinary tract infections: protein chemical and immunological aspects. Klemm P, et al. Infect Immun, 1982 May. PMID 6123483, Free PMC Article

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Donor strand sequence, rather than donor strand orientation, determines the stability and non-equilibrium folding of the type 1 pilus subunit FimA.
    Title: Donor strand sequence, rather than donor strand orientation, determines the stability and non-equilibrium folding of the type 1 pilus subunit FimA.
  2. X-ray structures of all three FimA monomers at 0.89-1.69 A resolutions, reveal identical, intramolecular donor-strand complementation mechanisms. Our results also showed that the pseudo-palindromic sequences of the donor strands in all FimA proteins permit their alternative folding possibilities.
    Title: Alternative folding to a monomer or homopolymer is a common feature of the type 1 pilus subunit FimA from enteroinvasive bacteria.
  3. FimA is capable of intramolecular self-complementation via its own donor strand, as evidenced by the loss of folding competence upon donor strand deletion.
    Title: Structure, folding and stability of FimA, the main structural subunit of type 1 pili from uropathogenic Escherichia coli strains.
  4. Results show that pilA recombinant protein has some immunoprotection effect with the challenging of virulent strains of E. coli GH1.2.
    Title: [Prokaryotic expression of pilA gene of type I pilus of enteropathogenic Escherichia coli isolated from ducks and the immunoprotection effect of recombinant expression protein challenged with virulent strains].
  5. report the identification of a soluble form of the pilus protein FimA from the culture supernatants of E. coli K1, Salmonella, and Shigella that can potently inhibit Bax-mediated release of cytochrome c from isolated mitochondria.
    Title: A soluble form of the pilus protein FimA targets the VDAC-hexokinase complex at mitochondria to suppress host cell apoptosis.
  6. N-terminus verified by Edman degradation on mature peptide
    Title: F7 and type 1-like fimbriae from three Escherichia coli strains isolated from urinary tract infections: protein chemical and immunological aspects.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell adhesion involved in single-species biofilm formation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in pilus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in pilus IEA
Inferred from Electronic Annotation
more info
  
located_in pilus RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 

General protein information

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Preferred Names
type 1 fimbriae major subunit

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4543115..4543663
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418734.1 type 1 fimbriae major subunit [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418734.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    Q4VU76
    Conserved Domains (1) summary
    cl01416
    Location:28 → 182
    Fimbrial; Fimbrial protein
Nucleotide Protein
Heading Accession and Version

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