U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

nudC RNA decapping hydrolase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948498, updated on 19-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
nudC
Official Full Name
RNA decapping hydrolase
Primary source
ECOCYC:EG11702
Locus tag
b3996
See related
ASAP:ABE-0013063
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3988; yjaD
Summary
Nudix hydrolase. [More information is available at EcoGene: EG11702]. NudC belongs to the family of "Nudix" hydrolases . [More information is available at EcoCyc: EG11702].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (4196903..4197676)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene thiamine phosphate synthase Neighboring gene phosphomethylpyrimidine synthase Neighboring gene regulator of sigma D Neighboring gene uroporphyrinogen decarboxylase Neighboring gene endonuclease V

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Structural basis of prokaryotic NAD-RNA decapping by NudC. Zhang D, et al. Cell Res, 2016 Sep. PMID 27561816, Free PMC Article
  2. Structure and function of the bacterial decapping enzyme NudC. Höfer K, et al. Nat Chem Biol, 2016 Sep. PMID 27428510, Free PMC Article
  3. NAD captureSeq indicates NAD as a bacterial cap for a subset of regulatory RNAs. Cahová H, et al. Nature, 2015 Mar 19. PMID 25533955
  4. An expanded genome-scale model of Escherichia coli K-12 (iJR904 GSM/GPR). Reed JL, et al. Genome Biol, 2003. PMID 12952533, Free PMC Article
  5. Comparison of the PhoPQ regulon in Escherichia coli and Salmonella typhimurium. Monsieurs P, et al. J Mol Evol, 2005 Apr. PMID 15883881

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. xray crystallography of NudC
    Title: Structural basis of prokaryotic NAD-RNA decapping by NudC.
  2. The Escherichia coli NudC strongly prefers NAD-linked RNA (NAD-RNA) over NAD and binds to a diverse set of cellular RNAs in an unspecific manner.
    Title: Structure and function of the bacterial decapping enzyme NudC.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables NAD+ diphosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables NAD+ diphosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables NADH pyrophosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NADH pyrophosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables NADH pyrophosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA NAD-cap (NMN-forming) hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA NAD-cap (NMN-forming) hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables manganese ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables manganese ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in NAD catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in NAD-cap decapping IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in NADH metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in NADP catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mRNA catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mRNA stabilization IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
RNA decapping hydrolase

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4196903..4197676
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_026280.1 RNA decapping hydrolase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for YP_026280.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376FUK0
    Conserved Domains (1) summary
    PRK00241
    Location:1 → 252
    nudC; NAD(+) diphosphatase
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.