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    mokC [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944756, updated on 24-Aug-2024

    Summary

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    Official Symbol
    mokC
    Primary source
    ASAP:ABE-0000064
    Locus tag
    b0018
    See related
    ECOCYC:EG10373
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0018; gefL
    Summary
    MokC translation enables HokC translation when MokC is not inhibited by the sokC sRNA. [More information is available at EcoGene: EG12074]. Sequence analysis indicates that the hokC gene is a homologue of the hok (host killing) gene which is responsible for mediating plasmid stabilization by post-segregational killing (PSK) in plasmid R1. hok encodes a stable mRNA whose translation is inhibited by a less stable mRNA encoded by sok. [More information is available at EcoCyc: EG10373].
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    Genomic context

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    Sequence:
    NC_000913.3 (16751..16960, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene chaperone protein DnaJ Neighboring gene IS186/IS421 family transposase Neighboring gene protein HokC Neighboring gene ncRNA Neighboring gene Na(+):H(+) antiporter NhaA Neighboring gene DNA-binding transcriptional activator NhaR

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The gef gene from Escherichia coli is regulated at the level of translation. Poulsen LK, et al. Mol Microbiol, 1991 Jul. PMID 1943701
    2. Antisense RNA-regulated programmed cell death. Gerdes K, et al. Annu Rev Genet, 1997. PMID 9442888
    3. Multiple hok genes on the chromosome of Escherichia coli. Pedersen K, et al. Mol Microbiol, 1999 Jun. PMID 10361310
    4. Membranome: a database for proteome-wide analysis of single-pass membrane proteins. Lomize AL, et al. Nucleic Acids Res, 2017 Jan 4. PMID 27510400, Free PMC Article
    5. RNA antitoxins. Gerdes K, et al. Curr Opin Microbiol, 2007 Apr. PMID 17376733

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Gene Ontology Provided by EcoCyc

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    regulatory protein MokC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      16751..16960 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414559.1 regulatory protein MokC [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414559.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0E0Y7P7, A0A0E2L9V5, A0A148HL80, A0A192CHU3, A0A236S5A7, A0A241QYV7, A0A3W5CTV9, A0AA36KTP8, A0AAD2RZD2, A0AAI9IPN9, B7MAD7, D8ACD3, Q1RGI6
      Conserved Domains (1) summary
      pfam01848
      Location:25 → 66
      HOK_GEF; Hok/gef family
    Nucleotide Protein
    Heading Accession and Version

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