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    aat-3 Large neutral amino acids transporter small subunit 1 [ Caenorhabditis elegans ]

    Gene ID: 180557, updated on 2-Nov-2024

    Summary

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    Official Symbol
    aat-3
    Official Full Name
    Large neutral amino acids transporter small subunit 1
    Primary source
    WormBase:WBGene00000004
    Locus tag
    CELE_F52H2.2
    See related
    AllianceGenome:WB:WBGene00000004
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Contributes to L-amino acid transmembrane transporter activity. Involved in amino acid transmembrane transport. Located in plasma membrane. Part of amino acid transport complex. Human ortholog(s) of this gene implicated in cholangiocarcinoma; colon cancer; hepatocellular carcinoma; and lung squamous cell carcinoma. Orthologous to human SLC7A5 (solute carrier family 7 member 5) and SLC7A8 (solute carrier family 7 member 8). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See aat-3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    12
    Sequence:
    Chromosome: X; NC_003284.9 (2552260..2557736)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Sodium-dependent multivitamin transporter Neighboring gene ncRNA Neighboring gene tRNA-Asn Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Asp Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Peptidase_M10 domain-containing protein Neighboring gene Diminuto-like protein;FAD-binding PCMH-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    contributes_to L-amino acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-alpha-amino acid transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amino acid transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of amino acid transport complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Large neutral amino acids transporter small subunit 1
    NP_001300351.1
    • Confirmed by transcript evidence
    NP_508461.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      2552260..2557736
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001313422.5 → NP_001300351.1  Large neutral amino acids transporter small subunit 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AVL7
      Conserved Domains (1) summary
      TIGR00911
      Location:40 → 527
      2A0308; L-type amino acid transporter

    2. NM_076060.7 → NP_508461.1  Large neutral amino acids transporter small subunit 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508461.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O17395
      Conserved Domains (1) summary
      TIGR00911
      Location:4 → 491
      2A0308; L-type amino acid transporter
    Nucleotide Protein
    Heading Accession and Version

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