COX11 Cox11p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: COX11
Official Full Name: Cox11p
Primary source: SGD:S000006053
Locus tag: YPL132W
See related: AllianceGenome:SGD:S000006053; FungiDB:YPL132W; VEuPathDB:YPL132W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: LPI13; PSO7
Summary: Enables copper ion binding activity. Involved in aerobic respiration; cell redox homeostasis; and protein-containing complex assembly. Located in mitochondrial inner membrane; mitochondrial intermembrane space; and mitochondrial ribosome. Is active in mitochondrion. Used to study mitochondrial complex IV deficiency nuclear type 23 and mitochondrial encephalomyopathy. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 23. Orthologous to human COX11 (cytochrome c oxidase copper chaperone COX11). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See COX11 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (301716..302618)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Novel COX11 Mutations Associated with Mitochondrial Disorder: Functional Characterization in Patient Fibroblasts and Saccharomyces cerevisiae.
Title: Novel COX11 Mutations Associated with Mitochondrial Disorder: Functional Characterization in Patient Fibroblasts and Saccharomyces cerevisiae.
The mitochondrial copper chaperone COX11 has an additional role in cellular redox homeostasis.
Title: The mitochondrial copper chaperone COX11 has an additional role in cellular redox homeostasis.
Data show that hydrogen peroxide sensitivity of sco1Delta and cox11Delta cells is abrogated by overexpression of a novel mitochondrial ATPase Afg1 that promotes the degradation of CcO mitochondrially encoded subunits.
Title: Evidence for a pro-oxidant intermediate in the assembly of cytochrome oxidase.
COX11 is an integral protein of the inner mitochondrial membrane that is essential for cytochrome c oxidase assembly.
Title: Mutational analysis of the Saccharomyces cerevisiae cytochrome c oxidase assembly protein Cox11p.
THe copper binding site is co-translationally formed by a transient interaction between Cox11 and the nascent cytochrome C oxidase in the intermembrane space.
Title: Evidence for the association of yeast mitochondrial ribosomes with Cox11p, a protein required for the Cu(B) site formation of cytochrome c oxidase.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables copper ion binding	IDA Inferred from Direct Assay more info	PubMed
enables copper ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in aerobic respiration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell redox homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein-containing complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial envelope	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial intermembrane space	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial ribosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Cox11p

NP_015193.1

Protein required for delivery of copper to Cox1p; mitochondrial inner membrane protein; involved in oxidative stress response; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

301716..302618

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183946.1 → NP_015193.1 TPA: Cox11p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015193.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W3N5, P19516

UniProtKB/TrEMBL

A6ZWC0, B3LKU3, B5VT33, C7GJ85, C8ZIP8, G2WP49, N1NVG3

Conserved Domains (1) summary

COG3175
Location:76 → 269

COX11; Cytochrome c oxidase assembly protein Cox11 [Energy production and conversion, Posttranslational modification, protein turnover, chaperones]