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    VRL1 Vrl1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855011, updated on 18-Sep-2024

    Summary

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    Official Symbol
    VRL1
    Official Full Name
    Vrl1p
    Primary source
    SGD:S000004461
    Locus tag
    YML002W
    See related
    AllianceGenome:SGD:S000004461; FungiDB:YML002W; VEuPathDB:YML002W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable SNARE binding activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in early endosome to late endosome transport. Predicted to be located in cytosol. Predicted to be active in cytoplasmic vesicle and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See VRL1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (264541..266754)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene lactoylglutathione lyase GLO1 Neighboring gene uncharacterized protein Neighboring gene Rab family GTPase YPT7 Neighboring gene polo kinase CDC5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-wide analysis of yeast transcription upon calcium shortage. Lombardía LJ, et al. Cell Calcium, 2002 Aug. PMID 12161108
    2. Vrl1 relies on its VPS9-domain to play a role in autophagy in Saccharomyces cerevisiae. Li W, et al. Cell Biol Int, 2019 Aug. PMID 31038239
    3. Response of genes associated with mitochondrial function to mild heat stress in yeast Saccharomyces cerevisiae. Sakaki K, et al. J Biochem, 2003 Sep. PMID 14561723
    4. Identification of genes affecting vacuole membrane fragmentation in Saccharomyces cerevisiae. Michaillat L, et al. PLoS One, 2013. PMID 23383298, Free PMC Article
    5. Yeast Nst1 is a novel component of P-bodies and is a specific suppressor of proteasome base assembly defects. Cheng CL, et al. Mol Biol Cell, 2021 Oct 1. PMID 34347506, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    Vrl1p
    NP_013712.1
    • hypothetical protein; expression induced by heat and by calcium shortage; in many strains, YML002W is continuous with YML003W, and is predicted to encode a single protein of 1090 aa with a full-length VPS9 domain; in strains S288C, W303, and CEN.PK, a single thymine residue is deleted near the 3' end of YML003W at ChrXIII:264337, causing a frameshift and premature stop codon, truncating YML003W

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      264541..266754
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182357.1 → NP_013712.1  TPA: Vrl1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013712.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZH3, P0CF17
      UniProtKB/TrEMBL
      N1P045
      Conserved Domains (1) summary
      cl19569
      Location:8 → 79
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CF17.1

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