PRS3 ribose phosphate diphosphokinase subunit PRS3 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: PRS3
Official Full Name: ribose phosphate diphosphokinase subunit PRS3
Primary source: SGD:S000001003
Locus tag: YHL011C
See related: AllianceGenome:SGD:S000001003; FungiDB:YHL011C; VEuPathDB:YHL011C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Contributes to ribose phosphate diphosphokinase activity. Involved in 5-phosphoribose 1-diphosphate biosynthetic process. Located in cytoplasm. Part of ribose phosphate diphosphokinase complex. Human ortholog(s) of this gene implicated in Arts syndrome; X-linked deafness 1; X-linked recessive disease (multiple); gout; and retinitis pigmentosa. Orthologous to human PRPS1 (phosphoribosyl pyrophosphate synthetase 1); PRPS1L1 (phosphoribosyl pyrophosphate synthetase 1 like 1); and PRPS2 (phosphoribosyl pyrophosphate synthetase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See PRS3 in Genome Data Viewer

Location:: chromosome: VIII

Exon count:: 1

Sequence:: Chromosome: VIII; NC_001140.6 (80654..81616, complement)

Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deletion of 284KKCPK288 pentameric motif from Prs3 destabilises the Prs1/Prs3 complex resulting in a cascade of events, including reduction in phosphoribosyl pyrophosphate synthetase activity and altered cell wall integrity (CWI) as measured by caffeine sensitivity and Rlm1 expression.
Title: The NHR1-1 of Prs1 and the pentameric motif 284KKCPK288 of Prs3 permit multi-functionality of the PRPP synthetase in Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ribose phosphate diphosphokinase activity	IEA Inferred from Electronic Annotation more info
contributes_to ribose phosphate diphosphokinase activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in 5-phosphoribose 1-diphosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in 5-phosphoribose 1-diphosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in 5-phosphoribose 1-diphosphate biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in 5-phosphoribose 1-diphosphate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in purine nucleotide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribonucleoside monophosphate biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of ribose phosphate diphosphokinase complex	IDA Inferred from Direct Assay more info	PubMed
part_of ribose phosphate diphosphokinase complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ribose phosphate diphosphokinase subunit PRS3

NP_011852.1

EC 2.7.6.1

5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001140.6 Reference assembly

Range

80654..81616 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179091.1 → NP_011852.1 TPA: ribose phosphate diphosphokinase subunit PRS3 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011852.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DKQ2, P38689

UniProtKB/TrEMBL

A6ZSP1, B3LSA8, B5VJR9, C7GIS6, C8ZA54, G2WF56, N1P336

Conserved Domains (1) summary

COG0462
Location:4 → 315

PrsA; Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism, Amino acid transport and metabolism]