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    flhD regulator of flagellar biosynthesis [ Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 ]

    Gene ID: 1253446, updated on 10-Oct-2024

    Summary

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    Gene symbol
    flhD
    Gene description
    regulator of flagellar biosynthesis
    Locus tag
    STM1925
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 (strain: LT2, serovar: Typhimurium, sub-species: enterica, culture-collection: ATCC:700720, culture-collection: SGSC:1412, type-material: type strain of Salmonella enterica)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Salmonella
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    Genomic context

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    Sequence:
    NC_003197.2 (2021714..2022215, complement)

    NC_003197.2Genomic Context describing neighboring genes Neighboring gene sensory histitine protein kinase Neighboring gene enables flagellar motor rotation Neighboring gene proton conductor component of motor Neighboring gene regulator of flagellar biosynthesis Neighboring gene putative cytoplasmic protein Neighboring gene putative universal stress protein Neighboring gene trehalose-6-phosphate synthase Neighboring gene trehalose-6-phosphate phophatase, biosynthetic

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003197.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Salmonella STM1697 coordinates flagella biogenesis and virulence by restricting flagellar master protein FlhD4C2 from recruiting RNA polymerase. Li B, et al. Nucleic Acids Res, 2017 Sep 29. PMID 28973452, Free PMC Article
    2. The Salmonella Spi1 virulence regulatory protein HilD directly activates transcription of the flagellar master operon flhDC. Singer HM, et al. J Bacteriol, 2014 Apr. PMID 24488311, Free PMC Article
    3. YdiV: a dual function protein that targets FlhDC for ClpXP-dependent degradation by promoting release of DNA-bound FlhDC complex. Takaya A, et al. Mol Microbiol, 2012 Mar. PMID 22380597, Free PMC Article
    4. Complete genome sequence of Salmonella enterica serovar Typhimurium LT2. McClelland M, et al. Nature, 2001 Oct 25. PMID 11677609

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Salmonella STM1697 coordinates flagella biogenesis and virulence by restricting flagellar master protein FlhD4C2 from recruiting RNA polymerase.
      Title: Salmonella STM1697 coordinates flagella biogenesis and virulence by restricting flagellar master protein FlhD4C2 from recruiting RNA polymerase.
    2. HilD transcriptionally activates flhDC gene expression by binding to nucleotides -68 to -24 upstream from the transcriptional start site.
      Title: The Salmonella Spi1 virulence regulatory protein HilD directly activates transcription of the flagellar master operon flhDC.
    3. YdiV targets FlhDC for ClpXP-dependent degradation by promoting release of DNA-bound FlhDC complex.
      Title: YdiV: a dual function protein that targets FlhDC for ClpXP-dependent degradation by promoting release of DNA-bound FlhDC complex.
    Submit: New GeneRIF Correction

    General gene information

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    regulatory

    • Loc: c2021723-2021718 regulatory_class = ribosome_binding_site
    • Loc: c2022077-2022072 regulatory_class = ribosome_binding_site
    • Loc: c2022196-2022188 regulatory_class = minus_10_signal
    • Loc: c2022215-2022207 regulatory_class = minus_35_signal

    General protein information

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    Preferred Names
    regulator of flagellar biosynthesis
    NP_460882.1
    • acts on class 2 operons; flagellar transcriptional activator FLHD. (SW:FLHD_SALTY)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003197.2 Reference assembly

      Range
      2021714..2022215 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_460882.1 regulator of flagellar biosynthesis [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]

      See identical proteins and their annotated locations for NP_460882.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2I5HFF6, A0A2T5MPR1, A0A3R0BTE9, A0A3R0Q7L8, A0A3U0D074, A0A3V4R5Y9, A0A5I2JZ85, A0A5T7HHL5, A0A5W8QU42, A0A5Y9I4I3, A0A6Y6FJV5, A0A701UVK0, A0A701V7I8, A0A707QRU6, A0A727TFJ1, A0A729J3K4, A0A731R8U7, A0A732CY93, A0A735L5N7, A0A735MA92, A0A736M9J7, A0A737LHU5, A0A752MR68
      Conserved Domains (1) summary
      PRK02909
      Location:4 → 107
      PRK02909; flagellar transcriptional regulator FlhD
    Nucleotide Protein
    Heading Accession and Version

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