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    slyA MarR family transcriptional regulator for hemolysin [ Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 ]

    Gene ID: 1252962, updated on 6-Jun-2024

    Summary

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    Gene symbol
    slyA
    Gene description
    MarR family transcriptional regulator for hemolysin
    Locus tag
    STM1444
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 (strain: LT2, serovar: Typhimurium, sub-species: enterica, culture-collection: ATCC:700720, culture-collection: SGSC:1412, type-material: type strain of Salmonella enterica)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Salmonella
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    Genomic context

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    Sequence:
    NC_003197.2 (1519865..1520311)

    NC_003197.2Genomic Context describing neighboring genes Neighboring gene copper/zinc superoxide dismutase Neighboring gene putative inner membrane protein Neighboring gene putative multidrug resistance efflux pump Neighboring gene putative inner membrane protein Neighboring gene putative outer membrane lipoprotein Neighboring gene putative cytoplasmic protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003197.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DNA recognition by the Salmonella enterica serovar Typhimurium transcription factor SlyA. Haider F, et al. Int Microbiol, 2008 Dec. PMID 19204896
    2. Identification of amino acid residues of Salmonella SlyA that are critical for transcriptional regulation. Okada N, et al. Microbiology (Reading), 2007 Feb. PMID 17259627
    3. Modulation of the regulatory activity of bacterial two-component systems by SlyA. Song H, et al. J Biol Chem, 2008 Oct 17. PMID 18678876, Free PMC Article
    4. SlyA and HilD Counteract H-NS-Mediated Repression on the ssrAB Virulence Operon of Salmonella enterica Serovar Typhimurium and Thus Promote Its Activation by OmpR. Banda MM, et al. J Bacteriol, 2019 Apr 15. PMID 30718301, Free PMC Article
    5. Crystal structures of SlyA protein, a master virulence regulator of Salmonella, in free and DNA-bound states. Dolan KT, et al. J Biol Chem, 2011 Jun 24. PMID 21550983, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data support two mechanisms adapted for the expression of ssrAB under different growth conditions. One involves the additive action of SlyA and HilD, whereas the other involves SlyA, but not HilD, to counteract H-NS-mediated repression on ssrAB, thus favoring in both cases the activation of ssrAB by OmpR.
      Title: SlyA and HilD Counteract H-NS-Mediated Repression on the ssrAB Virulence Operon of Salmonella enterica Serovar Typhimurium and Thus Promote Its Activation by OmpR.
    2. SlyA and other MarR global regulators rely more on indirect readout of DNA sequence to exert control over many genes
      Title: Crystal structures of SlyA protein, a master virulence regulator of Salmonella, in free and DNA-bound states.
    3. Systematic mutational analysis shows that no single base pair in the palindromic SlyA operator sequence is essential for DNA binding, and identifies amino acid residues required to allow SlyA to recognise DNA.
      Title: DNA recognition by the Salmonella enterica serovar Typhimurium transcription factor SlyA.
    4. SlyA has a role as a mediator in signal transduction from the PhoP/PhoQ system to other bacterial two-component systems in Salmonella
      Title: Modulation of the regulatory activity of bacterial two-component systems by SlyA.
    5. Residues Leu-63, Val-64, Arg-65, Leu-67, Leu-70, Arg-86 and Lys-88 are required for DNA binding, and residues Leu-12 and Leu-126 in the alpha-helices of the N- and C-terminal regions are required for dimer formation.
      Title: Identification of amino acid residues of Salmonella SlyA that are critical for transcriptional regulation.
    Submit: New GeneRIF Correction

    General gene information

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    regulatory

    • Loc: 1519865-1519870 regulatory_class = ribosome_binding_site

    General protein information

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    Preferred Names
    MarR family transcriptional regulator for hemolysin
    NP_460407.3
    • transcriptional regulator SLYA (salmolysin) (cytolysin SLYA). (SW:SLYA_SALTY)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003197.2 Reference assembly

      Range
      1519865..1520311
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      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_460407.3 MarR family transcriptional regulator for hemolysin [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A709X7E4, A0A722FG15, A0A724CBZ8, A0A732JX81, A0A740DLZ6, A0A742ZK26
      Conserved Domains (1) summary
      PRK03573
      Location:3 → 146
      PRK03573; transcriptional regulator SlyA; Provisional
    Nucleotide Protein
    Heading Accession and Version

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