U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    spvC Salmonella plasmid virulence: hydrophilic protein [ Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 ]

    Gene ID: 1256201, updated on 6-Oct-2023

    Summary

    Go to the top of the page Help
    Gene symbol
    spvC
    Gene description
    Salmonella plasmid virulence: hydrophilic protein
    Locus tag
    PSLT038
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 (strain: LT2, serovar: Typhimurium, sub-species: enterica, culture-collection: SGSC:1412, type-material: type strain of Salmonella enterica)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Salmonella
    Also known as
    spvB
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    plasmid: pSLT
    Sequence:
    NC_003277.2 (27178..27903, complement)

    NC_003277.2Genomic Context describing neighboring genes Neighboring gene putative transposase, IS200-like Neighboring gene Salmonella plasmid virulence: hydrophilic protein Neighboring gene Salmonella plasmid virulence: hydrophilic protein Neighboring gene Salmonella plasmid virulence: outer membrane protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003277.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Salmonella spvC Gene Inhibits Autophagy of Host Cells and Suppresses NLRP3 as Well as NLRC4. Zhou L, et al. Front Immunol, 2021. PMID 34335562, Free PMC Article
    2. Salmonella type III effector SpvC, a phosphothreonine lyase, contributes to reduction in inflammatory response during intestinal phase of infection. Haneda T, et al. Cell Microbiol, 2012 Apr. PMID 22188134
    3. SpvC is a Salmonella effector with phosphothreonine lyase activity on host mitogen-activated protein kinases. Mazurkiewicz P, et al. Mol Microbiol, 2008 Mar. PMID 18284579, Free PMC Article
    4. Antibiogram, Virulence Genes, and Biofilm-Forming Ability of Clinical Salmonella enterica Serovars: An In Vitro Study. Krishna D, et al. Microb Drug Resist, 2021 Jul. PMID 33305986
    5. Roles of spvB and spvC in S. Typhimurium colitis via the alternative pathway. Käppeli R, et al. Int J Med Microbiol, 2011 Feb. PMID 21036103

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Antibiogram, Virulence Genes, and Biofilm-Forming Ability of Clinical Salmonella enterica Serovars: An In Vitro Study.
      Title: Antibiogram, Virulence Genes, and Biofilm-Forming Ability of Clinical Salmonella enterica Serovars: An In Vitro Study.
    2. Salmonella spvC Gene Inhibits Autophagy of Host Cells and Suppresses NLRP3 as Well as NLRC4.
      Title: Salmonella spvC Gene Inhibits Autophagy of Host Cells and Suppresses NLRP3 as Well as NLRC4.
    3. SpvC can play a role in modulating the intensity of the inflammation as an anti-inflammatory effector and enhance Salmonella growth at the infection site.
      Title: Salmonella type III effector SpvC, a phosphothreonine lyase, contributes to reduction in inflammatory response during intestinal phase of infection.
    4. By 12h post infection, spvBC mutants elicited wild-type levels of gut inflammation and mucosal cytokine induction via the classical pathway. However, spvBC mutants confined to the alternative pathway triggered reduced levels of gut inflammation by day 3.
      Title: Roles of spvB and spvC in S. Typhimurium colitis via the alternative pathway.
    5. Data show that strains with a deletion in spvC showed attenuated for systemic virulence in mice, that SpvC has phosphothreonine lyase activity, and that strain expressing spvC from a plasmid downregulated cytokine release from infected cells.
      Title: SpvC is a Salmonella effector with phosphothreonine lyase activity on host mitogen-activated protein kinases.
    Submit: New GeneRIF Correction

    General protein information

    Go to the top of the page Help
    Preferred Names
    Salmonella plasmid virulence: hydrophilic protein

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003277.2 Reference assembly

      Range
      27178..27903 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_490528.1 Salmonella plasmid virulence: hydrophilic protein (plasmid) [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]

      See identical proteins and their annotated locations for NP_490528.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A3U2RZX1, A0A3U4KIB8, A0A3U7EDM8, A0A3Y0FIJ4, A0A5W6X620, A0A5Z8KX70, A0A604UKH6, A0A615M0U8, A0A707CDR7, A0A708C4V0, A0A712MAZ5, A0A734XUD6, A0A749KY32, Q04251
      Conserved Domains (1) summary
      PRK15245
      Location:1 → 241
      PRK15245; type III secretion system effector phosphothreonine lyase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    4HAH_A.1
    4HAH_B.1
    P0A2M9.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials