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    ADAMDEC1 ADAM like decysin 1 [ Homo sapiens (human) ]

    Gene ID: 27299, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ADAMDEC1provided by HGNC
    Official Full Name
    ADAM like decysin 1provided by HGNC
    Primary source
    HGNC:HGNC:16299
    See related
    Ensembl:ENSG00000134028 MIM:606393; AllianceGenome:HGNC:16299
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    M12.219
    Summary
    This encoded protein is thought to be a secreted protein belonging to the disintegrin metalloproteinase family. Its expression is upregulated during dendritic cells maturation. This protein may play an important role in dendritic cell function and their interactions with germinal center T cells. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in small intestine (RPKM 233.3), colon (RPKM 104.6) and 4 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ADAMDEC1 in Genome Data Viewer
    Location:
    8p21.2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (24384285..24406013)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (24659416..24681139)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (24241798..24263526)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986931 Neighboring gene uncharacterized LOC105379328 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:23963874-23964511 Neighboring gene MPRA-validated peak6951 silencer Neighboring gene ADAM7, ADAMDEC1 and ADAM28 antisense RNA 1 Neighboring gene ADAM metallopeptidase domain 28 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:24244666-24245865 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:24312019-24312518 Neighboring gene ADAM metallopeptidase domain 7 Neighboring gene ADAM7 antisense RNA 2 Neighboring gene uncharacterized LOC107986932

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. ADAMDEC1 is a metzincin metalloprotease with dampened proteolytic activity. Lund J, et al. J Biol Chem, 2013 Jul 19. PMID 23754285, Free PMC Article
    2. Polymerase chain reaction selects a novel disintegrin proteinase from CD40-activated germinal center dendritic cells. Mueller CG, et al. J Exp Med, 1997 Aug 29. PMID 9271581, Free PMC Article
    3. Inverse regulation of the ADAM-family members, decysin and MADDAM/ADAM19 during monocyte differentiation. Fritsche J, et al. Immunology, 2003 Dec. PMID 14632642, Free PMC Article
    4. Evidence for restricted reactivity of ADAMDEC1 with protein substrates and endogenous inhibitors. Lund J, et al. J Biol Chem, 2015 Mar 6. PMID 25564618, Free PMC Article
    5. ADAM-like Decysin-1 (ADAMDEC1) is a positive regulator of Epithelial Defense Against Cancer (EDAC) that promotes apical extrusion of RasV12-transformed cells. Yako Y, et al. Sci Rep, 2018 Jun 25. PMID 29941981, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Knockdown of ADAMDEC1 ameliorates ox-LDL-induced endothelial cell injury and atherosclerosis progression.
      Title: Knockdown of ADAMDEC1 ameliorates ox-LDL-induced endothelial cell injury and atherosclerosis progression.
    2. ADAMDEC1 induces EMT and promotes colorectal cancer cells metastasis by enhancing Wnt/beta-catenin signaling via negative modulation of GSK-3beta.
      Title: ADAMDEC1 induces EMT and promotes colorectal cancer cells metastasis by enhancing Wnt/β-catenin signaling via negative modulation of GSK-3β.
    3. Upregulation of ADAMDEC1 correlates with tumor progression and predicts poor prognosis in non-small cell lung cancer (NSCLC) via the PI3K/AKT pathway.
      Title: Upregulation of ADAMDEC1 correlates with tumor progression and predicts poor prognosis in non-small cell lung cancer (NSCLC) via the PI3K/AKT pathway.
    4. Knockdown of ADAMDEC1 inhibits the progression of glioma in vitro.
      Title: Knockdown of ADAMDEC1 inhibits the progression of glioma in vitro.
    5. ADAMDEC1 Maintains a Growth Factor Signaling Loop in Cancer Stem Cells.
      Title: ADAMDEC1 Maintains a Growth Factor Signaling Loop in Cancer Stem Cells.
    6. The ADAMDEC1 plays a pro-inflammatory role in rosacea via modulating the M1 polarization of macrophages.
      Title: ADAMDEC1 promotes skin inflammation in rosacea via modulating the polarization of M1 macrophages.
    7. ADAMDEC1 is a positive regulator of Epithelial Defense Against Cancer (EDAC) that promotes apical extrusion of RasV12-transformed cells
      Title: ADAM-like Decysin-1 (ADAMDEC1) is a positive regulator of Epithelial Defense Against Cancer (EDAC) that promotes apical extrusion of RasV12-transformed cells.
    8. Data show the critical pathways regulating the expression of ADAMDEC1 and the roles of enhancer RNAs and mechanistically links E1A binding protein p300 (p300) and enhancer RNAs, which is dependent on NF-kappa B (NFkappaB).
      Title: Enhancer RNA and NFκB-dependent P300 regulation of ADAMDEC1.
    9. Data suggest that activated platelets release ADAMDEC1, which hydrolyzes pro-EGF (epidermal growth factor) to soluble, active HMW-EGF; proteolytic cleavage of pro-EGF first occurs at the C-terminal arginyl residue of the EGF domain; proteolysis is the regulated, rate-limiting step in generating soluble EGF from activated platelets.
      Title: The soluble protease ADAMDEC1 released from activated platelets hydrolyzes platelet membrane pro-epidermal growth factor (EGF) to active high-molecular-weight EGF.
    10. We hypothesize that these unique features of ADAMDEC1 may have evolved to escape from inhibition by endogenous metalloprotease inhibitors
      Title: Evidence for restricted reactivity of ADAMDEC1 with protein substrates and endogenous inhibitors.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ79219

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables zinc ion binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in immune response NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of cell adhesion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ADAM DEC1
    Names
    ADAM-like protein decysin-1
    a disintegrin and metalloproteinase domain-like protein decysin-1
    decysin
    disintegrin protease

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145271.2 → NP_001138743.1  ADAM DEC1 isoform 2

      See identical proteins and their annotated locations for NP_001138743.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate exon compared to variant 1. Translation may initiate at an internal AUG site (compared to variant 1) due to leaky scanning as both AUG sites are associated with a weak Kozak signal. It is possible that this transcript is not protein-coding as initiation from the AUG site in exon 1 would render the transcript a candidate for nonsense-mediated decay. The same protein isoform is predicted for transcript variants 2 and 3.
      Source sequence(s)
      AK301007, AK316322
      Consensus CDS
      CCDS55212.1
      UniProtKB/TrEMBL
      B7Z6V5
      Conserved Domains (4) summary
      cd04269
      Location:139 → 330
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01421
      Location:139 → 333
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:3 → 93
      Pep_M12B_propep; Reprolysin family propeptide
      cl10507
      Location:350 → 382
      Disintegrin; Disintegrin

    2. NM_001145272.2 → NP_001138744.1  ADAM DEC1 isoform 2

      See identical proteins and their annotated locations for NP_001138744.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) omits an alternate exon compared to variant 1. Translation may initiate at an internal AUG site (compared to variant 1) due to leaky scanning as both AUG sites are associated with a weak Kozak signal. It is possible that this transcript is not protein-coding as initiation from the AUG site in exon 1 would render the transcript a candidate for nonsense-mediated decay. The same protein isoform is predicted for transcript variants 2 and 3.
      Source sequence(s)
      AK301007, BC069582
      Consensus CDS
      CCDS55212.1
      UniProtKB/TrEMBL
      B7Z6V5
      Related
      ENSP00000428993.1, ENST00000522298.1
      Conserved Domains (4) summary
      cd04269
      Location:139 → 330
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01421
      Location:139 → 333
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:3 → 93
      Pep_M12B_propep; Reprolysin family propeptide
      cl10507
      Location:350 → 382
      Disintegrin; Disintegrin

    3. NM_014479.3 → NP_055294.1  ADAM DEC1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_055294.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is predicted to encode the longer protein isoform (1) using a translation initiation site in the first exon.
      Source sequence(s)
      AK301007, BC069582, DC387711, Y13323
      Consensus CDS
      CCDS6044.1
      UniProtKB/Swiss-Prot
      B7ZAK5, O15204
      UniProtKB/TrEMBL
      B7Z6V5
      Related
      ENSP00000256412.4, ENST00000256412.8
      Conserved Domains (4) summary
      cd04269
      Location:218 → 409
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01421
      Location:218 → 412
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:54 → 172
      Pep_M12B_propep; Reprolysin family propeptide
      cl10507
      Location:429 → 461
      Disintegrin; Disintegrin

    RNA

    1. NR_156422.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AI801375, BX106677, BX481660, Y13323

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      24384285..24406013
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      24659416..24681139
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O15204.2 GenPept UniProtKB/Swiss-Prot:O15204

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