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    Alg2 ALG2, alpha-1,3/1,6-mannosyltransferase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38374, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Alg2provided by FlyBase
    Official Full Name
    ALG2, alpha-1,3/1,6-mannosyltransferaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035401
    Locus tag
    Dmel_CG1291
    See related
    AllianceGenome:FB:FBgn0035401
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1291; dAlg2; Dmel\CG1291
    Summary
    Predicted to enable alpha-1,3-mannosyltransferase activity. Predicted to be involved in dolichol-linked oligosaccharide biosynthetic process. Located in endomembrane system. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; embryonic/larval salivary gland; gut section; and salivary gland body primordium. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ii and congenital myasthenic syndrome 14. Orthologous to human ALG2 (ALG2 alpha-1,3/1,6-mannosyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See Alg2 in Genome Data Viewer
    Location:
    63B5-63B6; 3-6 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3143808..3145284)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3143808..3145284)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene prominin-like Neighboring gene transfer RNA:Methionine-CAT 2-1 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45819 Neighboring gene Ubiquitin specific protease 5 Neighboring gene BTB-protein-VII

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inter-cell type interactions that control JNK signaling in the Drosophila intestine. Zhang P, et al. Nat Commun, 2024 Jun 28. PMID 38944657, Free PMC Article
    2. Diversity and functions of protein glycosylation in insects. Walski T, et al. Insect Biochem Mol Biol, 2017 Apr. PMID 28232040
    3. Protein correlation profiles identify lipid droplet proteins with high confidence. Krahmer N, et al. Mol Cell Proteomics, 2013 May. PMID 23319140, Free PMC Article
    4. The RNA-Binding ATPase, Armitage, Couples piRNA Amplification in Nuage to Phased piRNA Production on Mitochondria. Ge DT, et al. Mol Cell, 2019 Jun 6. PMID 31076285, Free PMC Article
    5. Genes and biological processes controlled by the Drosophila FOXA orthologue Fork head. Liu Y, et al. Insect Mol Biol, 2008 Apr. PMID 18353099

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alpha-1,3-mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in dolichol-linked oligosaccharide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ALG2, alpha-1,3/1,6-mannosyltransferase
    Names
    A-1,3/A-1,6-mannosyltransferase
    Alg2-PA
    CG1291-PA
    NP_647772.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      3143808..3145284
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139515.5 → NP_647772.1  ALG2, alpha-1,3/1,6-mannosyltransferase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647772.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95SA2, Q9VZU8
      Related
      FBpp0072887
      Conserved Domains (2) summary
      cd03805
      Location:2 → 404
      GT1_ALG2_like; This family is most closely related to the GT1 family of glycosyltransferases. ALG2, a 1,3-mannosyltransferase, in yeast catalyzes the mannosylation of Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2) ...
      COG0438
      Location:1 → 412
      RfaB; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95SA2 Q95SA2
    Q9VZU8 Q9VZU8

    Gene LinkOut

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