REG Proteasome regulator gamma [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: REGprovided by FlyBase
Official Full Name: Proteasome regulator gammaprovided by FlyBase
Primary source: FLYBASE:FBgn0029133
Locus tag: Dmel_CG1591
See related: AllianceGenome:FB:FBgn0029133
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG1591; Dmel\CG1591; DmREGgamma; dReg; dREG; dReggamma; dREGgamma; REGgamma
Summary: Enables endopeptidase activator activity and endopeptidase inhibitor activity. Involved in regulation of G1/S transition of mitotic cell cycle and regulation of proteasomal protein catabolic process. Located in nucleus; polytene chromosome interband; and polytene chromosome puff. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Colocalizes with cytoplasm. Is expressed in several structures, including Malpighian tubule primordium; adult heart; amnioserosa; embryonic/larval midgut primordium; and head epidermis primordium. Orthologous to human PSME3 (proteasome activator subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (13212325..13214408)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (13106358..13108441)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables endopeptidase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables endopeptidase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables endopeptidase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in mRNA splicing, via spliceosome	IC Inferred by Curator more info	PubMed
involved_in positive regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of proteasomal protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of proteasomal protein catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of catalytic step 2 spliceosome	HDA more info	PubMed
colocalizes_with cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome interband	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome puff	IDA Inferred from Direct Assay more info	PubMed
part_of precatalytic spliceosome	HDA more info	PubMed
part_of proteasome activator complex	IEA Inferred from Electronic Annotation more info

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