lin lines [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: linprovided by FlyBase
Official Full Name: linesprovided by FlyBase
Primary source: FLYBASE:FBgn0002552
Locus tag: Dmel_CG11770
See related: AllianceGenome:FB:FBgn0002552
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG11770; Dmel\CG11770; Lin
Summary: Involved in several processes, including digestive tract morphogenesis; proximal/distal axis specification; and spiracle morphogenesis, open tracheal system. Located in cytoplasm and nucleus. Is expressed in several structures, including embryonic epidermis; embryonic hindgut; inclusive hindgut primordium; mesoderm; and stomodeum. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 27. Orthologous to human LINS1 (lines homolog 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 44F6-44F7; 2-59 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (8914524..8918234)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (4802029..4805739)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lines acts antagonistically to bowl in hub specification, establishing bowl as a positively acting factor in the development of the testis niche.
Title: lines and bowl affect the specification of cyst stem cells and niche cells in the Drosophila testis.
by preventing Bowl accumulation in the wing, primordial Lines permits the correct balance of nuclear co-repressors that control the activity of the Wingless, Notch and Hedgehog pathways
Title: Lines is required for normal operation of Wingless, Hedgehog and Notch pathways during wing development.
Here we show that Lines accumulates in nuclei in the presumptive tarsus and the inter-joints of proximal leg segments and governs the formation of these structures by destabilizing the nuclear protein Bowl
Title: Essential roles for lines in mediating leg and antennal proximodistal patterning and generating a stable Notch signaling interface at segment borders.
Reciprocal roles are reported for bowl and lin in specifying the peripodial epithelum and the disc proper of the wing.
Title: Reciprocal roles for bowl and lines in specifying the peripodial epithelium and the disc proper of the Drosophila wing primordium.
Drm and Lines regulate Bowl protein accumulation and consequent patterning in the epithelia of the foregut, hindgut, and imaginal discs.
Title: The Drumstick/Lines/Bowl regulatory pathway links antagonistic Hedgehog and Wingless signaling inputs to epidermal cell differentiation.
data show that drm encodes a zinc finger protein that is a member of the Odd-skipped family. drm expression is localized to the developing midgut-hindgut junction, while lines is broadly expressed throughout the gut primordium
Title: Drumstick is a zinc finger protein that antagonizes Lines to control patterning and morphogenesis of the Drosophila hindgut.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in embryonic foregut morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic hindgut morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epidermis development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in foregut morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hindgut morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proximal/distal axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spiracle morphogenesis, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: lines

Names: CG11770-PA; lin-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

8914524..8918234

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_080076.3 → NP_524815.1 lines [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524815.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9V4Z9

UniProtKB/TrEMBL

Q2XY68

Related

FBpp0087732

Conserved Domains (2) summary

pfam14694
Location:442 → 801

LINES_N; Lines N-terminus

pfam14695
Location:814 → 849

LINES_C; Lines C-terminus