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    MED21 mediator 21 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 825815, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MED21
    Official Full Name
    mediator 21
    Primary source
    TAIR:AT4G04780
    Locus tag
    AT4G04780
    See related
    Araport:AT4G04780
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    mediator 21; T4B21.8; T4B21_8
    Summary
    Encodes the med21 subunit of the mediator complex which is involved in transcriptional regulation. MED21 interacts physically with the E3 ligase HUB1 and this interaction may be important in mediation defense responses to fungal pathogens.
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    Genomic context

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    See MED21 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    4
    Sequence:
    Chromosome: 4; NC_003075.7 (2432252..2433635)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Major facilitator superfamily protein Neighboring gene ATP binding cassette protein 1 Neighboring gene zinc ion binding protein Neighboring gene ncRNA Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. HISTONE MONOUBIQUITINATION1 interacts with a subunit of the mediator complex and regulates defense against necrotrophic fungal pathogens in Arabidopsis. Dhawan R, et al. Plant Cell, 2009 Mar. PMID 19286969, Free PMC Article
    2. Repression by the Arabidopsis TOPLESS corepressor requires association with the core mediator complex. Leydon AR, et al. Elife, 2021 Jun 2. PMID 34075876, Free PMC Article
    3. Purification of a plant mediator from Arabidopsis thaliana identifies PFT1 as the Med25 subunit. Bäckström S, et al. Mol Cell, 2007 Jun 8. PMID 17560376
    4. LIK1, a CERK1-interacting kinase, regulates plant immune responses in Arabidopsis. Le MH, et al. PLoS One, 2014. PMID 25036661, Free PMC Article
    5. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_116716.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mediator complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in polar nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mediator 21
    NP_192387.2
    • mediator 21 (MED21); CONTAINS InterPro DOMAIN/s: Mediator complex, subunit Med21 (InterPro:IPR021384); Has 261 Blast hits to 261 proteins in 70 species: Archae - 0; Bacteria - 2; Metazoa - 108; Fungi - 6; Plants - 134; Viruses - 7; Other Eukaryotes - 4 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      2432252..2433635
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_116716.5 → NP_192387.2  mediator 21 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_192387.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0LU16, Q84WP9, Q9M0Z8, Q9ZS95
      UniProtKB/TrEMBL
      A0A178V2S7, A0A5S9XPV0
      Conserved Domains (1) summary
      pfam11221
      Location:2 → 130
      Med21; Subunit 21 of Mediator complex
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    C0LU16.1

    Gene LinkOut

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