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    NIMIN1 NIM1-interacting 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837800, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NIMIN1
    Official Full Name
    NIM1-interacting 1
    Primary source
    TAIR:AT1G02450
    Locus tag
    AT1G02450
    See related
    Araport:AT1G02450
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    NIM1-interacting 1; NIMIN-1; T6A9.23
    Summary
    NIMIN1 modulates PR gene expression according the following model: NPR1 forms a ternary complex with NIMIN1 and TGA factors upon SAR induction that binds to a positive regulatory cis-element of the PR-1 promoter, termed LS7. This leads to PR-1 gene induction. NIMIN1 decreases transcriptional activation, possibly through its EAR motif, which results in fine-tuning of PR-1 gene expression.
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    Genomic context

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    See NIMIN1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    1
    Sequence:
    Chromosome: 1; NC_003070.9 (497917..498539, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ADP-ribosylation factor D1B Neighboring gene ncRNA Neighboring gene ADP-ribosylation factor D1A Neighboring gene Pectin lyase-like superfamily protein Neighboring gene Polyketide cyclase/dehydrase and lipid transport superfamily protein Neighboring gene Polyketide cyclase/dehydrase and lipid transport superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression of Arabidopsis NIMIN1 results in salicylate intolerance. Mohan R, et al. Plant Signal Behav, 2016 Oct 2. PMID 27429420, Free PMC Article
    2. Functional analysis of a TGA factor-binding site located in the promoter region controlling salicylic acid-induced NIMIN-1 expression in Arabidopsis. Fonseca JP, et al. Genet Mol Res, 2010 Feb 2. PMID 20198573
    3. Interaction of NIMIN1 with NPR1 modulates PR gene expression in Arabidopsis. Weigel RR, et al. Plant Cell, 2005 Apr. PMID 15749762, Free PMC Article
    4. NIMIN-1, NIMIN-2 and NIMIN-3, members of a novel family of proteins from Arabidopsis that interact with NPR1/NIM1, a key regulator of systemic acquired resistance in plants. Weigel RR, et al. Plant Mol Biol, 2001 May. PMID 11442055
    5. Posttranslational Modifications of the Master Transcriptional Regulator NPR1 Enable Dynamic but Tight Control of Plant Immune Responses. Saleh A, et al. Cell Host Microbe, 2015 Aug 12. PMID 26269953, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results indicate that over-accumulation of a negative regulator renders plants hypersensitive to SA by limiting NPR1 function. Furthermore, NPR1 activates negative regulators such as NIMIN1 for feedback inhibition of SA signaling to maintain immune homeostasis.
      Title: Overexpression of Arabidopsis NIMIN1 results in salicylate intolerance.
    2. TGA2-binding motif is directly involved in the modulation of salicylic acid-induced NIMIN-1 expression in Arabidopsis.
      Title: Functional analysis of a TGA factor-binding site located in the promoter region controlling salicylic acid-induced NIMIN-1 expression in Arabidopsis.
    3. NIMIN1 negatively regulates distinct functions of NPR1, providing a mechanism to modulate specific features of SAR.[NIMIN1]
      Title: Interaction of NIMIN1 with NPR1 modulates PR gene expression in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_100126.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of systemic acquired resistance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    NIM1-interacting 1
    NP_563653.2
    • NIM1-interacting 1 (NIMIN1); FUNCTIONS IN: protein binding; INVOLVED IN: regulation of systemic acquired resistance, defense response to bacterium, negative regulation of transcription; LOCATED IN: nucleus; EXPRESSED IN: 20 plant structures; EXPRESSED DURING: 13 growth stages; BEST Arabidopsis thaliana protein match is: systemic acquired resistance (SAR) regulator protein NIMIN-1-related (TAIR:AT4G01895.1); Has 50 Blast hits to 50 proteins in 12 species: Archae - 0; Bacteria - 0; Metazoa - 5; Fungi - 2; Plants - 35; Viruses - 0; Other Eukaryotes - 8 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      497917..498539 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100126.4 → NP_563653.2  NIM1-interacting 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_563653.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FNZ5, Q9FWX4
      UniProtKB/TrEMBL
      A0A178WC43, A0A5S9S8P5, A0A654EGT2
      Conserved Domains (1) summary
      pfam15699
      Location:44 → 138
      NPR1_interact; NPR1 interacting
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FNZ5.1

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