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    MEMB12 membrin 12 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835112, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MEMB12
    Official Full Name
    membrin 12
    Primary source
    TAIR:AT5G50440
    Locus tag
    AT5G50440
    See related
    Araport:AT5G50440
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATMEMB12; membrin 12; MXI22.16; MXI22_16
    Summary
    Member of Membrin Gene Family. Encodes a Golgi-localized SNARE protein MEMB12. MEMB12 is a target of miR393b-mediated gene silencing during Pseudomonas syringae pv. Tomato infection. Loss of function of MEMB12 leads to increased exocytosis of an antimicrobial pathogenesis-related protein, PR1.
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    Genomic context

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    See MEMB12 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    4
    Sequence:
    Chromosome: 5; NC_003076.8 (20537426..20538996, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Putative membrane lipoprotein Neighboring gene ubiquitin-conjugating enzyme 33 Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene HCP-like superfamily protein with MYND-type zinc finger

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis Argonaute 2 regulates innate immunity via miRNA393(∗)-mediated silencing of a Golgi-localized SNARE gene, MEMB12. Zhang X, et al. Mol Cell, 2011 May 6. PMID 21549312, Free PMC Article
    2. Signal motif-dependent ER export of the Qc-SNARE BET12 interacts with MEMB12 and affects PR1 trafficking in Arabidopsis. Chung KP, et al. J Cell Sci, 2018 Jan 29. PMID 28546447
    3. Routes to the tonoplast: the sorting of tonoplast transporters in Arabidopsis mesophyll protoplasts. Wolfenstetter S, et al. Plant Cell, 2012 Jan. PMID 22253225, Free PMC Article
    4. Uncovering Arabidopsis membrane protein interactome enriched in transporters using mating-based split ubiquitin assays and classification models. Chen J, et al. Front Plant Sci, 2012. PMID 22737156, Free PMC Article
    5. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Endoplasmic reticulum-export-defective form of BET12 revealed that the Golgi-localized Qb-SNARE MEMB12, a negative regulator of pathogenesis-related protein 1 (PR1; At2g14610) secretion, was its interacting partner.
      Title: Signal motif-dependent ER export of the Qc-SNARE BET12 interacts with MEMB12 and affects PR1 trafficking in Arabidopsis.
    2. Results show that AGO2-bound small RNA miR393b( *) targets a Golgi-localized SNARE gene, MEMB12.
      Title: Arabidopsis Argonaute 2 regulates innate immunity via miRNA393(∗)-mediated silencing of a Golgi-localized SNARE gene, MEMB12.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001344893.1
    NM_124426.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables SNAP receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cis-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    membrin 12
    NP_199855.1
    • membrin 12 (MEMB12); BEST Arabidopsis thaliana protein match is: membrin 11 (TAIR:AT2G36900.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      20537426..20538996 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124426.5 → NP_199855.1  membrin 12 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199855.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FK28
      UniProtKB/TrEMBL
      A0A178UID9, Q541Y1
      Conserved Domains (1) summary
      cd15863
      Location:127 → 192
      SNARE_GS27; SNARE motif of GS27

    2. NM_001344893.1 → NP_001330036.1  membrin 12 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FK28
      UniProtKB/TrEMBL
      A0A178UID9, Q541Y1
      Conserved Domains (1) summary
      cd15863
      Location:127 → 192
      SNARE_GS27; SNARE motif of GS27
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FK28.1

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