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    CRF2 cytokinin response factor 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828475, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CRF2
    Official Full Name
    cytokinin response factor 2
    Primary source
    TAIR:AT4G23750
    Locus tag
    AT4G23750
    See related
    Araport:AT4G23750
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    cytokinin response factor 2; F9D16.220; F9D16_220; TARGET OF MONOPTEROS 3; TMO3
    Summary
    encodes a member of the ERF (ethylene response factor) subfamily B-5 of ERF/AP2 transcription factor family. The protein contains one AP2 domain. There are 7 members in this subfamily. Monopteros target gene.
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    Genomic context

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    See CRF2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    1
    Sequence:
    Chromosome: 4; NC_003075.7 (12376122..12378032)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Leucine-rich repeat protein kinase family protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Cox19-like CHCH family protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CRF2 signaling is a novel regulator of cellular adhesion and migration in colorectal cancer cells. Ducarouge B, et al. PLoS One, 2013. PMID 24260200, Free PMC Article
    2. CYTOKININ RESPONSE FACTOR2 (CRF2) and CRF3 Regulate Lateral Root Development in Response to Cold Stress in Arabidopsis. Jeon J, et al. Plant Cell, 2016 Aug. PMID 27432872, Free PMC Article
    3. MONOPTEROS controls embryonic root initiation by regulating a mobile transcription factor. Schlereth A, et al. Nature, 2010 Apr 8. PMID 20220754
    4. A subset of Arabidopsis AP2 transcription factors mediates cytokinin responses in concert with a two-component pathway. Rashotte AM, et al. Proc Natl Acad Sci U S A, 2006 Jul 18. PMID 16832061, Free PMC Article
    5. CRFs form protein-protein interactions with each other and with members of the cytokinin signalling pathway in Arabidopsis via the CRF domain. Cutcliffe JW, et al. J Exp Bot, 2011 Oct. PMID 21705390, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_118506.3
    NM_202870.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cotyledon development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within root development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    cytokinin response factor 2
    NP_194106.1
    • cytokinin response factor 2 (CRF2); CONTAINS InterPro DOMAIN/s: DNA-binding, integrase-type (InterPro:IPR016177), Pathogenesis-related transcriptional factor/ERF, DNA-binding (InterPro:IPR001471); BEST Arabidopsis thaliana protein match is: cytokinin response factor 1 (TAIR:AT4G11140.1); Has 5899 Blast hits to 5717 proteins in 251 species: Archae - 0; Bacteria - 0; Metazoa - 6; Fungi - 2; Plants - 5881; Viruses - 0; Other Eukaryotes - 10 (source: NCBI BLink).
    NP_974599.1
    • cytokinin response factor 2 (CRF2); CONTAINS InterPro DOMAIN/s: DNA-binding, integrase-type (InterPro:IPR016177), Pathogenesis-related transcriptional factor/ERF, DNA-binding (InterPro:IPR001471); BEST Arabidopsis thaliana protein match is: cytokinin response factor 1 (TAIR:AT4G11140.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      12376122..12378032
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118506.3 → NP_194106.1  cytokinin response factor 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194106.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8L701, Q9SUQ2
      UniProtKB/TrEMBL
      A0A178V319, A0A5S9XVL7
      Conserved Domains (1) summary
      smart00380
      Location:121 → 181
      AP2; DNA-binding domain in plant proteins such as APETALA2 and EREBPs

    2. NM_202870.1 → NP_974599.1  cytokinin response factor 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974599.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8L701, Q9SUQ2
      UniProtKB/TrEMBL
      A0A178V319, A0A5S9XVL7
      Conserved Domains (1) summary
      smart00380
      Location:121 → 181
      AP2; DNA-binding domain in plant proteins such as APETALA2 and EREBPs
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SUQ2.1

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