DET1 light-mediated development protein 1 / deetiolated1 (DET1) [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: DET1
Official Full Name: light-mediated development protein 1 / deetiolated1 (DET1)
Primary source: TAIR:AT4G10180
Locus tag: AT4G10180
See related: Araport:AT4G10180
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATDET1; DE-ETIOLATED 1; FUS2; FUSCA 2; T9A4.17
Summary: Encodes a nuclear-localized protein that acts as a repressor of photomorphogenesis and may be involved in chromatin remodeling.
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Genomic context

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See DET1 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 10

Sequence:: Chromosome: 4; NC_003075.7 (6346411..6349314)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DET1-mediated COP1 regulation avoids HY5 activity over second-site gene targets to tune plant photomorphogenesis.
Title: DET1-mediated COP1 regulation avoids HY5 activity over second-site gene targets to tune plant photomorphogenesis.
DET1 regulates HY5 through COP1: A new paradigm in the regulation of HY5.
Title: DET1 regulates HY5 through COP1: A new paradigm in the regulation of HY5.
Mutation of CONSTITUTIVELY PHOTOMORPOGENIC1 (COP1), DE-ETIOLATED1, and CYTOKININ INSENSITIVE4/COP10 renders plants insensitive to cytokinin, and these factors are indispensable for the transcriptional response during cytokinin-induced de-etiolation, indicating that a functional light-signaling pathway is essential for this cytokinin response.
Title: Ethylene-independent promotion of photomorphogenesis in the dark by cytokinin requires COP1 and the CDD complex.
Authors show that a common signaling module integrates environmental signals, such as photoperiod and temperature, to regulate the growth-defense balance. Key light-signaling components De-Etiolated 1 (DET1) and Constitutive Photomorphogenic 1 (COP1) negatively regulate immunity and are essential for immune modulation by photoperiod and temperature.
Title: DET1 and COP1 Modulate the Coordination of Growth and Immunity in Response to Key Seasonal Signals in Arabidopsis.
DET1-DDB1-Associated-1 (DDA1) protein interacts with SGF11 in vivo, linking the DET1 complex to light-dependent ubiquitin-mediated proteolytic degradation of the deubiquitination module.
Title: DET1-mediated degradation of a SAGA-like deubiquitination module controls H2Bub homeostasis.
These findings reveal a mechanistic framework in which DET1/COP1 and HY5 regulatory modules act independently to regulate growth through the environmental signal integrator PIF4.
Title: DET1 and HY5 Control PIF4-Mediated Thermosensory Elongation Growth through Distinct Mechanisms.
Germination in det1 mutants is sensitive to ABA. Double mutant analysis indicates that det1 abscisic acid sensitive germination requires HY5 and ABI5.
Title: Genetic interactions between DET1 and intermediate genes in Arabidopsis ABA signalling.
DET1 is a strong repressor of flowering and has a pivotal role in maintaining photoperiod sensitivity in the regulation of flowering time.
Title: Negative regulatory roles of DE-ETIOLATED1 in flowering time in Arabidopsis.
PEX2 RING domain overexpression in det1 also partially suppresses the det1 phenotype.
Title: Ectopic expression of the RING domain of the Arabidopsis peroxin2 protein partially suppresses the phenotype of the photomorphogenic mutant de-etiolated1.
Genomic analysis also revealed that DET1 may modulate the expression of light-regulated genes to mediate photomorphogenesis partially through phytochrome-interacting factors.
Title: Arabidopsis DE-ETIOLATED1 represses photomorphogenesis by positively regulating phytochrome-interacting factors in the dark.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_117086.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of photomorphogenesis	IMP Inferred from Mutant Phenotype more info

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: light-mediated development protein 1 / deetiolated1 (DET1)

NP_192756.2

DE-ETIOLATED 1 (DET1); FUNCTIONS IN: catalytic activity; INVOLVED IN: DNA repair, negative regulation of photomorphogenesis; LOCATED IN: nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: De-etiolated protein 1, Det1 (InterPro:IPR019138), Six-hairpin glycosidase-like (InterPro:IPR008928); Has 248 Blast hits to 240 proteins in 75 species: Archae - 0; Bacteria - 0; Metazoa - 106; Fungi - 0; Plants - 132; Viruses - 0; Other Eukaryotes - 10 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

6346411..6349314

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_117086.4 → NP_192756.2 light-mediated development protein 1 / deetiolated1 (DET1) [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_192756.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P48732, Q66GQ4

UniProtKB/TrEMBL

A0A5S9XSQ7, A0A654FMZ2

Conserved Domains (1) summary

pfam09737
Location:122 → 542

Det1; De-etiolated protein 1 Det1