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    IAA7 indole-3-acetic acid 7 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821879, updated on 18-Sep-2024

    Summary

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    Official Symbol
    IAA7
    Official Full Name
    indole-3-acetic acid 7
    Primary source
    TAIR:AT3G23050
    Locus tag
    AT3G23050
    See related
    Araport:AT3G23050
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AUXIN RESISTANT 2; AXR2; indole-3-acetic acid 7
    Summary
    Transcription regulator acting as repressor of auxin-inducible gene expression. Plays role in the control of gravitropic growth and development in light-grown seedlings. Auxin induces the degradation of the protein in a dosage-dependent manner in a process mediated by AtRac1. Auxin induced the relocalization of the protein within the nucleus from a diffused nucleoplasmic pattern to a discrete particulated pattern named nuclear protein bodies or NPB in a process also mediated by Rac1. Colocalizes with SCF, CSN and 26S proteasome components. Pseudomonas syringae type III effector AvrRpt2 stimulates AXR2 protein turnover.
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    Genomic context

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    See IAA7 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    5
    Sequence:
    Chromosome: 3; NC_003074.8 (8194606..8197161)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene indole-3-acetic acid inducible 2 Neighboring gene ncRNA Neighboring gene RING/U-box superfamily protein Neighboring gene CRM family member 3A Neighboring gene Polyketide cyclase/dehydrase and lipid transport superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A dominant mutation in Arabidopsis confers resistance to auxin, ethylene and abscisic acid. Wilson AK, et al. Mol Gen Genet, 1990 Jul. PMID 2148800
    2. A gain-of-function mutation in IAA7/AXR2 confers late flowering under short-day light in Arabidopsis. Mai YX, et al. J Integr Plant Biol, 2011 Jun. PMID 21564544
    3. The Pseudomonas syringae type III effector AvrRpt2 promotes pathogen virulence via stimulating Arabidopsis auxin/indole acetic acid protein turnover. Cui F, et al. Plant Physiol, 2013 Jun. PMID 23632856, Free PMC Article
    4. Light-dependent gravitropism and negative phototropism of inflorescence stems in a dominant Aux/IAA mutant of Arabidopsis thaliana, axr2. Sato A, et al. J Plant Res, 2014 Sep. PMID 24938853
    5. The small molecule 2-furylacrylic acid inhibits auxin-mediated responses in Arabidopsis thaliana. Sungur C, et al. Plant Cell Physiol, 2007 Dec. PMID 17942448

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest that AXR2-dependent auxin response in the endodermis plays a more crucial role in gravitropism than in phototropism in stems but no significant roles in either tropism in hypocotyls.
      Title: Light-dependent gravitropism and negative phototropism of inflorescence stems in a dominant Aux/IAA mutant of Arabidopsis thaliana, axr2.
    2. Pseudomonas syringae type III effector AvrRpt2 promotes pathogen virulence via stimulating Arabidopsis AXR2 protein turnover. [AXR2]
      Title: The Pseudomonas syringae type III effector AvrRpt2 promotes pathogen virulence via stimulating Arabidopsis auxin/indole acetic acid protein turnover.
    3. IAA7/AXR2 might act to inhibit the timing of floral transition under short day light.
      Title: A gain-of-function mutation in IAA7/AXR2 confers late flowering under short-day light in Arabidopsis.
    4. Data propose that ABA represses embryonic axis elongation by potentiating auxin signaling in its elongation zone. This involves repression of IAA7, encoding a key component of ABA- and auxin-dependent responses during postgerminative growth.
      Title: Abscisic acid represses growth of the Arabidopsis embryonic axis after germination by enhancing auxin signaling.
    5. There are functional differences among the Aux/IAA gene family members MSG2, AXR2, and SLR.
      Title: Specificity and similarity of functions of the Aux/IAA genes in auxin signaling of Arabidopsis revealed by promoter-exchange experiments among MSG2/IAA19, AXR2/IAA7, and SLR/IAA14.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001338610.1
    NM_113205.3
    NM_202626.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within gravitropism IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to auxin TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to jasmonic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to water deprivation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to wounding IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    indole-3-acetic acid 7
    NP_188945.1
    • indole-3-acetic acid 7 (IAA7); CONTAINS InterPro DOMAIN/s: Aux/IAA-ARF-dimerisation (InterPro:IPR011525), AUX/IAA protein (InterPro:IPR003311); BEST Arabidopsis thaliana protein match is: indole-3-acetic acid inducible 14 (TAIR:AT4G14550.1); Has 1682 Blast hits to 1681 proteins in 74 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 1681; Viruses - 0; Other Eukaryotes - 1 (source: NCBI BLink).
    NP_974355.1
    • indole-3-acetic acid 7 (IAA7); CONTAINS InterPro DOMAIN/s: Aux/IAA-ARF-dimerisation (InterPro:IPR011525), AUX/IAA protein (InterPro:IPR003311); BEST Arabidopsis thaliana protein match is: indole-3-acetic acid inducible 14 (TAIR:AT4G14550.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      8194606..8197161
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_113205.3 → NP_188945.1  indole-3-acetic acid 7 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188945.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q38825, Q8LAK1
      UniProtKB/TrEMBL
      A0A5S9XEX8, A0A654FA11
      Conserved Domains (1) summary
      pfam02309
      Location:10 → 233
      AUX_IAA; AUX/IAA family

    2. NM_001338610.1 → NP_001326465.1  indole-3-acetic acid 7 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VD03, A0A1I9LPC8

    3. NM_202626.2 → NP_974355.1  indole-3-acetic acid 7 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974355.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654FA11, F4J2U7
      Conserved Domains (1) summary
      pfam02309
      Location:10 → 210
      AUX_IAA; AUX/IAA family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q38825.1

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