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    DJ1A Class I glutamine amidotransferase-like superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820728, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DJ1A
    Official Full Name
    Class I glutamine amidotransferase-like superfamily protein
    Primary source
    TAIR:AT3G14990
    Locus tag
    AT3G14990
    See related
    Araport:AT3G14990
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtDJ1A; DJ-1 homolog A; DJ-1a
    Summary
    Encodes a homolog of animal DJ-1 superfamily protein. In the A. thaliana genome, three genes encoding close homologs of human DJ-1 were identified AT3G14990 (DJ1A), AT1G53280 (DJ1B) and AT4G34020 (DJ1C). Among the three homologs, DJ1C is essential for chloroplast development and viability. It exhibits glyoxalase activity towards glyoxal and methylglyoxal.
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    Genomic context

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    See DJ1A in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    8
    Sequence:
    Chromosome: 3; NC_003074.8 (5047376..5049971)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene RING/U-box superfamily protein Neighboring gene Acyl-CoA N-acyltransferase with RING/FYVE/PHD-type zinc finger protein Neighboring gene uncharacterized protein Neighboring gene cobalt ion binding protein Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene Lactate/malate dehydrogenase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ROS removal by DJ-1: Arabidopsis as a new model to understand Parkinson's Disease. Xu XM, et al. Plant Signal Behav, 2010 Aug. PMID 20671441, Free PMC Article
    2. Novel glyoxalases from Arabidopsis thaliana. Kwon K, et al. FEBS J, 2013 Jul. PMID 23651081
    3. The Arabidopsis DJ-1a protein confers stress protection through cytosolic SOD activation. Xu XM, et al. J Cell Sci, 2010 May 15. PMID 20406884
    4. The plasmodesmal protein PDLP1 localises to haustoria-associated membranes during downy mildew infection and regulates callose deposition. Caillaud MC, et al. PLoS Pathog, 2014 Oct. PMID 25393742, Free PMC Article
    5. The vegetative vacuole proteome of Arabidopsis thaliana reveals predicted and unexpected proteins. Carter C, et al. Plant Cell, 2004 Dec. PMID 15539469, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DJ-1 directly influences SOD activity in a highly conserved manner to remove ROS, thereby preventing cell death.
      Title: ROS removal by DJ-1: Arabidopsis as a new model to understand Parkinson's Disease.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001035621.1
    NM_112361.5
    NM_180257.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables glyoxalase III activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of cellular response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    Class I glutamine amidotransferase-like superfamily protein
    NP_001030698.1
    • Class I glutamine amidotransferase-like superfamily protein; FUNCTIONS IN: catalytic activity; INVOLVED IN: response to cadmium ion, thiamin biosynthetic process; LOCATED IN: plasma membrane, vacuole; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: DJ-1 (InterPro:IPR006287), ThiJ/PfpI (InterPro:IPR002818); BEST Arabidopsis thaliana protein match is: Class I glutamine amidotransferase-like superfamily protein (TAIR:AT1G53280.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_188117.1
    • Class I glutamine amidotransferase-like superfamily protein; FUNCTIONS IN: catalytic activity; INVOLVED IN: response to cadmium ion, thiamin biosynthetic process; LOCATED IN: plasma membrane, vacuole; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: DJ-1 (InterPro:IPR006287), ThiJ/PfpI (InterPro:IPR002818); BEST Arabidopsis thaliana protein match is: Class I glutamine amidotransferase-like superfamily protein (TAIR:AT1G53280.1); Has 10802 Blast hits to 6415 proteins in 1883 species: Archae - 336; Bacteria - 9086; Metazoa - 526; Fungi - 85; Plants - 335; Viruses - 0; Other Eukaryotes - 434 (source: NCBI BLink).
    NP_850588.1
    • Class I glutamine amidotransferase-like superfamily protein; FUNCTIONS IN: catalytic activity; INVOLVED IN: response to cadmium ion, thiamin biosynthetic process; LOCATED IN: plasma membrane, vacuole; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: DJ-1 (InterPro:IPR006287), ThiJ/PfpI (InterPro:IPR002818); BEST Arabidopsis thaliana protein match is: Class I glutamine amidotransferase-like superfamily protein (TAIR:AT1G53280.1); Has 10809 Blast hits to 6441 proteins in 1899 species: Archae - 334; Bacteria - 9077; Metazoa - 525; Fungi - 83; Plants - 359; Viruses - 0; Other Eukaryotes - 431 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      5047376..5049971
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112361.5 → NP_188117.1  Class I glutamine amidotransferase-like superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188117.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FPF0, Q9LKA6
      UniProtKB/TrEMBL
      A0A178VPH3, A0A5S9XDN4
      Conserved Domains (2) summary
      cd03135
      Location:231 → 377
      GATase1_DJ-1; Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1
      TIGR01383
      Location:7 → 185
      not_thiJ; DJ-1 family protein

    2. NM_001035621.1 → NP_001030698.1  Class I glutamine amidotransferase-like superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001030698.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FPF0
      Conserved Domains (1) summary
      cd03135
      Location:208 → 354
      GATase1_DJ-1; Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1

    3. NM_180257.1 → NP_850588.1  Class I glutamine amidotransferase-like superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850588.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FPF0
      Conserved Domains (1) summary
      cd03135
      Location:208 → 354
      GATase1_DJ-1; Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FPF0.1

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