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    GOX2 Aldolase-type TIM barrel family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820664, updated on 7-Sep-2023

    Summary

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    Gene symbol
    GOX2
    Gene description
    Aldolase-type TIM barrel family protein
    Primary source
    Araport:AT3G14415
    Locus tag
    AT3G14415
    See related
    TAIR:AT3G14415
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    glycolate oxidase 2
    Summary
    Encodes a glycolate oxidase that modulates reactive oxygen species-mediated signal transduction during nonhost resistance.
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    Genomic context

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    See GOX2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    12
    Sequence:
    Chromosome: 3; NC_003074.8 (4818251..4821013)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ubiquitin-specific protease 25 Neighboring gene Nucleotide/sugar transporter family protein Neighboring gene Aldolase-type TIM barrel family protein Neighboring gene GRIP/coiled-coil protein Neighboring gene nine-cis-epoxycarotenoid dioxygenase 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lack of GLYCOLATE OXIDASE1, but Not GLYCOLATE OXIDASE2, Attenuates the Photorespiratory Phenotype of CATALASE2-Deficient Arabidopsis. Kerchev P, et al. Plant Physiol, 2016 Jul. PMID 27225899, Free PMC Article
    2. Glycolate oxidase modulates reactive oxygen species-mediated signal transduction during nonhost resistance in Nicotiana benthamiana and Arabidopsis. Rojas CM, et al. Plant Cell, 2012 Jan. PMID 22286136, Free PMC Article
    3. Interactome analysis reveals versatile functions of Arabidopsis COLD SHOCK DOMAIN PROTEIN 3 in RNA processing within the nucleus and cytoplasm. Kim MH, et al. Cell Stress Chaperones, 2013 Jul. PMID 23334891, Free PMC Article
    4. Proteome analysis of Arabidopsis leaf peroxisomes reveals novel targeting peptides, metabolic pathways, and defense mechanisms. Reumann S, et al. Plant Cell, 2007 Oct. PMID 17951448, Free PMC Article
    5. The 14-3-3 isoforms chi and epsilon differentially bind client proteins from developing Arabidopsis seed. Swatek KN, et al. J Proteome Res, 2011 Sep 2. PMID 21766784

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GOX2 role in photorespiration.
      Title: Lack of GLYCOLATE OXIDASE1, but Not GLYCOLATE OXIDASE2, Attenuates the Photorespiratory Phenotype of CATALASE2-Deficient Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001202962.1
    NM_001202963.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables (S)-2-hydroxy-acid oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FMN binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hydrogen peroxide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oxidative photosynthetic carbon pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apoplast HDA PubMed 
    located_in chloroplast HDA PubMed 
    located_in chloroplast stroma HDA PubMed 
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in peroxisome HDA PubMed 
    located_in plant-type vacuole HDA PubMed 

    General protein information

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    Preferred Names
    Aldolase-type TIM barrel family protein
    NP_001189891.1
    • Aldolase-type TIM barrel family protein; FUNCTIONS IN: glycolate oxidase activity, oxidoreductase activity, FMN binding, catalytic activity; INVOLVED IN: oxidation reduction, metabolic process; LOCATED IN: peroxisome; EXPRESSED IN: guard cell, leaf; CONTAINS InterPro DOMAIN/s: Aldolase-type TIM barrel (InterPro:IPR013785), FMN-dependent alpha-hydroxy acid dehydrogenase, active site (InterPro:IPR008259), FMN-dependent dehydrogenase (InterPro:IPR000262), Alpha-hydroxy acid dehydrogenase, FMN-dependent (InterPro:IPR012133); BEST Arabidopsis thaliana protein match is: Aldolase-type TIM barrel family protein (TAIR:AT3G14420.2).
    NP_001189892.1
    • Aldolase-type TIM barrel family protein; FUNCTIONS IN: glycolate oxidase activity, oxidoreductase activity, FMN binding, catalytic activity; INVOLVED IN: oxidation reduction, metabolic process; LOCATED IN: peroxisome; EXPRESSED IN: guard cell, leaf; CONTAINS InterPro DOMAIN/s: Aldolase-type TIM barrel (InterPro:IPR013785), FMN-dependent alpha-hydroxy acid dehydrogenase, active site (InterPro:IPR008259), FMN-dependent dehydrogenase (InterPro:IPR000262), Alpha-hydroxy acid dehydrogenase, FMN-dependent (InterPro:IPR012133); BEST Arabidopsis thaliana protein match is: Aldolase-type TIM barrel family protein (TAIR:AT3G14420.2).
    NP_188059.1
    • Aldolase-type TIM barrel family protein; FUNCTIONS IN: glycolate oxidase activity, oxidoreductase activity, FMN binding, catalytic activity; INVOLVED IN: oxidation reduction, metabolic process; LOCATED IN: in 6 components; EXPRESSED IN: cotyledon, fruit, guard cell, juvenile leaf, leaf; EXPRESSED DURING: seedling growth; CONTAINS InterPro DOMAIN/s: Aldolase-type TIM barrel (InterPro:IPR013785), FMN-dependent alpha-hydroxy acid dehydrogenase, active site (InterPro:IPR008259), FMN-dependent dehydrogenase (InterPro:IPR000262), Alpha-hydroxy acid dehydrogenase, FMN-dependent (InterPro:IPR012133); BEST Arabidopsis thaliana protein match is: Aldolase-type TIM barrel family protein (TAIR:AT3G14420.2); Has 11834 Blast hits to 11812 proteins in 1926 species: Archae - 158; Bacteria - 5520; Metazoa - 369; Fungi - 693; Plants - 265; Viruses - 0; Other Eukaryotes - 4829 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      4818251..4821013
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112301.3 → NP_188059.1  Aldolase-type TIM barrel family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188059.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q56XF8, Q9LRS0
      UniProtKB/TrEMBL
      A0A178VBY9, A0A5S9XCL6
      Conserved Domains (1) summary
      PLN02493
      Location:1 → 367
      PLN02493; probable peroxisomal (S)-2-hydroxy-acid oxidase

    2. NM_001202963.1 → NP_001189892.1  Aldolase-type TIM barrel family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001189892.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q56XF8, Q9LRS0
      UniProtKB/TrEMBL
      A0A178VBY9, A0A5S9XCL6
      Conserved Domains (1) summary
      PLN02493
      Location:1 → 367
      PLN02493; probable peroxisomal (S)-2-hydroxy-acid oxidase

    3. NM_001202962.1 → NP_001189891.1  Aldolase-type TIM barrel family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001189891.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VD55, A0A384L6X3, A0A5S9XCL6, F4JFV6
      Conserved Domains (2) summary
      PLN02493
      Location:1 → 373
      PLN02493; probable peroxisomal (S)-2-hydroxy-acid oxidase
      cd02809
      Location:8 → 357
      alpha_hydroxyacid_oxid_FMN; Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LRS0.1

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