PP2CA protein phosphatase 2CA [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: PP2CA
Official Full Name: protein phosphatase 2CA
Primary source: TAIR:AT3G11410
Locus tag: AT3G11410
See related: Araport:AT3G11410
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AHG3; ARABIDOPSIS THALIANA PROTEIN PHOSPHATASE 2CA; ATPP2CA; protein phosphatase 2CA
Summary: Encodes protein phosphatase 2C. Negative regulator of ABA signalling. Expressed in seeds during germination. mRNA up-regulated by drought and ABA.
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Genomic context

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See PP2CA in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 4

Sequence:: Chromosome: 3; NC_003074.8 (3583782..3585850, complement)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PIR1 and PIR2 play a positive role in abscisic acid (ABA) signaling via modulation of PP2CA stability. The findings provide insight into modulation of PP2C in ABA signaling in Arabidopsis.
Title: The RING finger E3 ligases PIR1 and PIR2 mediate PP2CA degradation to enhance abscisic acid response in Arabidopsis.
The interaction of AtPP2CA with "phosphorylated" or "dephosphorylated" GORK systematically led to inhibition of the channel to the same baseline level.
Title: The Arabidopsis AtPP2CA Protein Phosphatase Inhibits the GORK K+ Efflux Channel and Exerts a Dominant Suppressive Effect on Phosphomimetic-activating Mutations.
Intercellular communication in Arabidopsis thaliana pollen discovered via AHG3 transcript movement from the vegetative cell to sperm.
Title: Intercellular communication in Arabidopsis thaliana pollen discovered via AHG3 transcript movement from the vegetative cell to sperm.
ABI1 and PP2CA dephosphorylate and inactivate SnRK1 which represses SnRK1 signaling.
Title: ABI1 and PP2CA phosphatases are negative regulators of Snf1-related protein kinase1 signaling in Arabidopsis.
The structure of PP2CA revealed an uncharacterized CCCH zinc-finger motif.
Title: Molecular basis for the selective and ABA-independent inhibition of PP2CA by PYL13.
Data indicate that PYL8 interacted in vivo with at least five PP2Cs, namely HAB1, HAB2, ABI1, ABI2, and PP2CA.
Title: PYRABACTIN RESISTANCE1-LIKE8 plays an important role for the regulation of abscisic acid signaling in root.
These findings provide further insights into the signaling network consisting of CBL-CIPK-PP2C interactions in the activation of the AKT1 channel.
Title: Mechanistic analysis of AKT1 regulation by the CBL-CIPK-PP2CA interactions.
Data show that a PP2C-type phosphatase (renamed PIA1) was identified that accumulates following infection by Pseudomonas syringae expressing AvrRpm1 and subsequent activation of the corresponding plant NB-LRR disease resistance protein RPM1.
Title: A protein phosphatase 2C, responsive to the bacterial effector AvrRpm1 but not to the AvrB effector, regulates defense responses in Arabidopsis.
The AtPP2CA protein phosphatase is a strong negative regulator of ABA signal transduction. [AtPP2CA]
Title: The protein phosphatase AtPP2CA negatively regulates abscisic acid signal transduction in Arabidopsis, and effects of abh1 on AtPP2CA mRNA.
ABA-hypersensitive germination3 (AHG3)encodes AtPP2CA that functions as a negative regulator of the ABA-signaling pathway and plays a major role in ABA signaling in seed germination and early growth. [AHG3]
Title: ABA-hypersensitive germination3 encodes a protein phosphatase 2C (AtPP2CA) that strongly regulates abscisic acid signaling during germination among Arabidopsis protein phosphatase 2Cs.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_111974.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphoprotein phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein serine/threonine phosphatase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within abscisic acid-activated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within abscisic acid-activated signaling pathway	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of abscisic acid-activated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of stomatal movement	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to abscisic acid	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to abscisic acid	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to cold	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to water deprivation	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: protein phosphatase 2CA

NP_187748.1

protein phosphatase 2CA (PP2CA); FUNCTIONS IN: protein binding, protein serine/threonine phosphatase activity, phosphoprotein phosphatase activity; INVOLVED IN: in 6 processes; LOCATED IN: protein serine/threonine phosphatase complex; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Protein phosphatase 2C, manganese/magnesium aspartate binding site (InterPro:IPR000222), Protein phosphatase 2C-related (InterPro:IPR001932), Protein phosphatase 2C (InterPro:IPR015655), Protein phosphatase 2C, N-terminal (InterPro:IPR014045); BEST Arabidopsis thaliana protein match is: highly ABA-induced PP2C gene 2 (TAIR:AT1G07430.1); Has 6894 Blast hits to 6854 proteins in 510 species: Archae - 4; Bacteria - 413; Metazoa - 1689; Fungi - 773; Plants - 2747; Viruses - 7; Other Eukaryotes - 1261 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

3583782..3585850 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_111974.4 → NP_187748.1 protein phosphatase 2CA [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_187748.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P49598

UniProtKB/TrEMBL

A0A178VB35

Conserved Domains (1) summary

smart00332
Location:106 → 349

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain