SWP RNA polymerase II transcription mediator [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: SWP
Official Full Name: RNA polymerase II transcription mediator
Primary source: TAIR:AT3G04740
Locus tag: AT3G04740
See related: Araport:AT3G04740
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS MEDIATOR COMPONENTS 14; ATMED14; F7O18.23; F7O18_23; MED14; MEDIATOR COMPONENTS 14; STRUWWELPETER
Summary: encodes a protein with similarities to subunits of the Mediator complex, required for RNA polymerase II recruitment at target promoters in response to specific activators. Lines carrying loss of function mutations in the gene have reduced cell numbers in aerial organs. On the other hand, lines overexpressing the gene have increased number of small cells in clusters, suggesting cell division is more unsynchronized in the overexpressors.Required for expression of CBF-controlled cold-responsive genes. Required for recruitment of the Mediator complex and RNA polymerase II to CBF-controlled cold-responsive genes. Required for expression of some dark-upregulated genes.
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Genomic context

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See SWP in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 8

Sequence:: Chromosome: 3; NC_003074.8 (1293798..1300792)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Differential requirement of MED14/17 recruitment for activation of heat inducible genes.
Title: Differential requirement of MED14/17 recruitment for activation of heat inducible genes.
Med14 and Med17 emerged as the key components of the Arabidopsis Mediator complex providing important scaffold for the whole complex.
Title: Interaction map of Arabidopsis Mediator complex expounding its topology.
RNA polymerase II recruitment to CBF-responsive cold-regulated genes requires MED16, MED2, and MED14 subunits.
Title: The Arabidopsis mediator complex subunits MED16, MED14, and MED2 regulate mediator and RNA polymerase II recruitment to CBF-responsive cold-regulated genes.
The Arabidopsis Mediator complex subunits MED14 and MED16 differentially regulate defense gene expression in plant immune responses.
Title: The Arabidopsis Mediator complex subunits MED14/SWP and MED16/SFR6/IEN1 differentially regulate defense gene expression in plant immune responses.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_111346.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription coregulator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within abscisic acid-activated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cold acclimation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of thermomorphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of plant organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to temperature stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within systemic acquired resistance	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
part_of mediator complex	IDA Inferred from Direct Assay more info	PubMed
part_of mediator complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info
located_in plasmodesma	HDA more info	PubMed

General protein information

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Preferred Names: RNA polymerase II transcription mediator

NP_187125.1

STRUWWELPETER (SWP); FUNCTIONS IN: RNA polymerase II transcription mediator activity; INVOLVED IN: positive regulation of transcription, positive regulation of cell proliferation; LOCATED IN: mediator complex; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Mediator complex, subunit Med14 (InterPro:IPR013947); Has 940 Blast hits to 375 proteins in 163 species: Archae - 0; Bacteria - 61; Metazoa - 117; Fungi - 104; Plants - 74; Viruses - 0; Other Eukaryotes - 584 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

1293798..1300792

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_111346.4 → NP_187125.1 RNA polymerase II transcription mediator [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_187125.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9SR02

UniProtKB/TrEMBL

A0A178VAI6, A0A5S9X9R6, A0A654F9D6

Conserved Domains (1) summary

pfam08638
Location:8 → 198

Med14; Mediator complex subunit MED14