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    ALDH6B2 aldehyde dehydrogenase 6B2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 815903, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ALDH6B2
    Official Full Name
    aldehyde dehydrogenase 6B2
    Primary source
    TAIR:AT2G14170
    Locus tag
    AT2G14170
    See related
    Araport:AT2G14170
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    aldehyde dehydrogenase 6B2; aldehyde dehydrogenase 6B2; T22C12.10; T22C12_10
    Summary
    Arabidopsis thaliana methylmalonate-semialdehyde dehydrogenase
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    Genomic context

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    See ALDH6B2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    19
    Sequence:
    Chromosome: 2; NC_003071.7 (5977272..5981899, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene pseudo Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lipoic acid-dependent oxidative catabolism of alpha-keto acids in mitochondria provides evidence for branched-chain amino acid catabolism in Arabidopsis. Taylor NL, et al. Plant Physiol, 2004 Feb. PMID 14764908, Free PMC Article
    2. The impact of oxidative stress on Arabidopsis mitochondria. Sweetlove LJ, et al. Plant J, 2002 Dec. PMID 12492832
    3. Analysis of the Arabidopsis mitochondrial proteome. Millar AH, et al. Plant Physiol, 2001 Dec. PMID 11743115, Free PMC Article
    4. Divalent metal ions in plant mitochondria and their role in interactions with proteins and oxidative stress-induced damage to respiratory function. Tan YF, et al. Plant Physiol, 2010 Feb. PMID 20018591, Free PMC Article
    5. Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins. Heazlewood JL, et al. Plant Cell, 2004 Jan. PMID 14671022, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001084418.1
    NM_001084419.1
    NM_126989.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables copper ion binding HDA PubMed 
    enables methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    aldehyde dehydrogenase 6B2
    NP_001077887.1
    • aldehyde dehydrogenase 6B2 (ALDH6B2); CONTAINS InterPro DOMAIN/s: Aldehyde/histidinol dehydrogenase (InterPro:IPR016161), Aldehyde dehydrogenase (InterPro:IPR015590), Aldehyde dehydrogenase, N-terminal (InterPro:IPR016162), Aldehyde dehydrogenase, conserved site (InterPro:IPR016160), Methylmalonate-semialdehyde dehydrogenase (InterPro:IPR010061); BEST Arabidopsis thaliana protein match is: aldehyde dehydrogenase 2C4 (TAIR:AT3G24503.1); Has 57678 Blast hits to 57389 proteins in 2927 species: Archae - 475; Bacteria - 33277; Metazoa - 2527; Fungi - 2072; Plants - 1211; Viruses - 0; Other Eukaryotes - 18116 (source: NCBI BLink).
    NP_001077888.1
    • aldehyde dehydrogenase 6B2 (ALDH6B2); CONTAINS InterPro DOMAIN/s: Aldehyde/histidinol dehydrogenase (InterPro:IPR016161), Aldehyde dehydrogenase (InterPro:IPR015590), Aldehyde dehydrogenase, N-terminal (InterPro:IPR016162), Aldehyde dehydrogenase, conserved site (InterPro:IPR016160), Methylmalonate-semialdehyde dehydrogenase (InterPro:IPR010061); BEST Arabidopsis thaliana protein match is: aldehyde dehydrogenase 2C4 (TAIR:AT3G24503.1); Has 57527 Blast hits to 57240 proteins in 2927 species: Archae - 475; Bacteria - 33264; Metazoa - 2506; Fungi - 2072; Plants - 1211; Viruses - 0; Other Eukaryotes - 17999 (source: NCBI BLink).
    NP_179032.1
    • aldehyde dehydrogenase 6B2 (ALDH6B2); FUNCTIONS IN: 3-chloroallyl aldehyde dehydrogenase activity, copper ion binding; INVOLVED IN: response to oxidative stress; LOCATED IN: mitochondrion; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Aldehyde/histidinol dehydrogenase (InterPro:IPR016161), Aldehyde dehydrogenase (InterPro:IPR015590), Aldehyde dehydrogenase, N-terminal (InterPro:IPR016162), Aldehyde dehydrogenase, conserved site (InterPro:IPR016160), Methylmalonate-semialdehyde dehydrogenase (InterPro:IPR010061); BEST Arabidopsis thaliana protein match is: aldehyde dehydrogenase 2C4 (TAIR:AT3G24503.1); Has 57810 Blast hits to 57524 proteins in 2942 species: Archae - 475; Bacteria - 33374; Metazoa - 2527; Fungi - 2116; Plants - 1215; Viruses - 0; Other Eukaryotes - 18103 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      5977272..5981899 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_126989.2 → NP_179032.1  aldehyde dehydrogenase 6B2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_179032.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WM29, Q9SI43
      UniProtKB/TrEMBL
      A0A178VQ51
      Conserved Domains (2) summary
      cd07085
      Location:114 → 590
      ALDH_F6_MMSDH; Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2
      PLN02419
      Location:1 → 604
      PLN02419; methylmalonate-semialdehyde dehydrogenase [acylating]

    2. NM_001084419.1 → NP_001077888.1  aldehyde dehydrogenase 6B2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001077888.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VQ51, A8MQH4
      Conserved Domains (2) summary
      cd07085
      Location:114 → 584
      ALDH_F6_MMSDH; Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2
      PLN02419
      Location:1 → 574
      PLN02419; methylmalonate-semialdehyde dehydrogenase [acylating]

    3. NM_001084418.1 → NP_001077887.1  aldehyde dehydrogenase 6B2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001077887.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VQ51, A8MQR6
      Conserved Domains (1) summary
      cd07085
      Location:5 → 481
      ALDH_F6_MMSDH; Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0WM29.2

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