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    HGPT Hypoxanthine-guanine phosphoribosyltransferase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843505, updated on 15-Oct-2023

    Summary

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    Gene symbol
    HGPT
    Gene description
    Hypoxanthine-guanine phosphoribosyltransferase
    Primary source
    Araport:AT1G71750
    Locus tag
    AT1G71750
    See related
    TAIR:AT1G71750
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F14O23.13; F14O23_13; Hypoxanthine-guanine phosphoribosyltransferase
    Summary
    Encodes a protein with hypoxanthine-guanine-phosphoribosyltransferase activity. Unlike some related enzymes, it does not appear to act on xanthine in vitro. The enzyme catalyzes reactions occurring in both directions, but appears to prefer acting on guanine, followed by hypoxanthine, in vitro. The enzyme is likely to function in purine salvage pathways and appears to be important for seed germination.
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    Genomic context

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    See HGPT in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    4
    Sequence:
    Chromosome: 1; NC_003070.9 (26987775..26989199, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Nucleic acid-binding proteins superfamily Neighboring gene uncharacterized protein Neighboring gene nucleolar protein Neighboring gene uncharacterized protein Neighboring gene poly(A)-binding protein 5 Neighboring gene WD repeat protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular and functional analysis of hypoxanthine-guanine phosphoribosyltransferase from Arabidopsis thaliana. Liu X, et al. New Phytol, 2007. PMID 17635220
    2. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    NM_001198443.1
    NM_105833.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables guanine phosphoribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hypoxanthine phosphoribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hypoxanthine phosphoribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in IMP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within guanine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within hypoxanthine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within seed germination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Hypoxanthine-guanine phosphoribosyltransferase
    NP_001185372.1
    • Hypoxanthine-guanine phosphoribosyltransferase (HGPT); FUNCTIONS IN: transferase activity, hypoxanthine phosphoribosyltransferase activity; INVOLVED IN: guanine metabolic process, nucleoside metabolic process, seed germination, hypoxanthine metabolic process; LOCATED IN: cytoplasm; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Hypoxanthine phosphoribosyl transferase (InterPro:IPR005904), Phosphoribosyltransferase (InterPro:IPR000836).
    NP_177320.1
    • Hypoxanthine-guanine phosphoribosyltransferase (HGPT); FUNCTIONS IN: transferase activity, hypoxanthine phosphoribosyltransferase activity; INVOLVED IN: guanine metabolic process, nucleoside metabolic process, seed germination, hypoxanthine metabolic process; LOCATED IN: cytoplasm; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Phosphoribosyltransferase (InterPro:IPR000836), Hypoxanthine phosphoribosyl transferase (InterPro:IPR005904); Has 5577 Blast hits to 5577 proteins in 2200 species: Archae - 45; Bacteria - 4400; Metazoa - 260; Fungi - 2; Plants - 42; Viruses - 0; Other Eukaryotes - 828 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      26987775..26989199 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001198443.1 → NP_001185372.1  Hypoxanthine-guanine phosphoribosyltransferase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185372.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4IA25, Q682L7
      Conserved Domains (1) summary
      PLN02238
      Location:1 → 198
      PLN02238; hypoxanthine phosphoribosyltransferase

    2. NM_105833.4 → NP_177320.1  Hypoxanthine-guanine phosphoribosyltransferase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_177320.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WFM2, Q682L7, Q8L8L7
      Conserved Domains (1) summary
      PLN02238
      Location:1 → 188
      PLN02238; hypoxanthine phosphoribosyltransferase
    Nucleotide Protein
    Heading Accession and Version

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