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    DIN9 Mannose-6-phosphate isomerase, type I [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843027, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DIN9
    Official Full Name
    Mannose-6-phosphate isomerase, type I
    Primary source
    TAIR:AT1G67070
    Locus tag
    AT1G67070
    See related
    Araport:AT1G67070
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    DARK INDUCIBLE 9; F1O19.12; F1O19_12; PHOSPHOMANNOSE ISOMERASE 2; PMI2
    Summary
    Encodes a protein with phosphomannose isomerase activity that is involved in synthesis of ascorbic acid. Expression is induced after 24 hours of dark treatment, in senescing leaves and treatment with exogenous photosynthesis inhibitor. Induction of gene expression was suppressed in excised leaves supplied with sugar. The authors suggest that the gene's expression pattern is responding to the level of sugar in the cell.
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    Genomic context

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    See DIN9 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    5
    Sequence:
    Chromosome: 1; NC_003070.9 (25041833..25044659)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene peptidase M50B-like protein Neighboring gene abscisic acid (aba)-deficient 4 Neighboring gene ribulose bisphosphate carboxylase small chain 1A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Response to darkness of late-responsive dark-inducible genes is positively regulated by leaf age and negatively regulated by calmodulin-antagonist-sensitive signalling in Arabidopsis thaliana. Fujiki Y, et al. Plant Cell Physiol, 2005 Oct. PMID 16100230
    2. Dark-inducible genes from Arabidopsis thaliana are associated with leaf senescence and repressed by sugars. Fujiki Y, et al. Physiol Plant, 2001 Mar. PMID 11240919
    3. Arabidopsis phosphomannose isomerase 1, but not phosphomannose isomerase 2, is essential for ascorbic acid biosynthesis. Maruta T, et al. J Biol Chem, 2008 Oct 24. PMID 18755683, Free PMC Article
    4. Multiple signaling pathways in gene expression during sugar starvation. Pharmacological analysis of din gene expression in suspension-cultured cells of Arabidopsis. Fujiki Y, et al. Plant Physiol, 2000 Nov. PMID 11080291, Free PMC Article
    5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    NM_001334269.1
    NM_001334270.1
    NM_105377.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables mannose-6-phosphate isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mannose-6-phosphate isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in GDP-mannose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within L-ascorbic acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to DDT IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to L-ascorbic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to absence of light IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to cadmium ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to sucrose IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to zinc ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Mannose-6-phosphate isomerase, type I
    NP_001319330.1
    • DARK INDUCIBLE 9 (DIN9); CONTAINS InterPro DOMAIN/s: Mannose-6-phosphate isomerase (InterPro:IPR016305), Cupin, RmlC-type (InterPro:IPR011051), Mannose-6-phosphate isomerase, type I (InterPro:IPR001250), RmlC-like jelly roll fold (InterPro:IPR014710), Phosphomannose isomerase, type I, conserved site (InterPro:IPR018050); BEST Arabidopsis thaliana protein match is: Mannose-6-phosphate isomerase, type I (TAIR:AT3G02570.1); Has 2340 Blast hits to 2321 proteins in 789 species: Archae - 2; Bacteria - 1171; Metazoa - 570; Fungi - 215; Plants - 90; Viruses - 0; Other Eukaryotes - 292 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      25041833..25044659
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001334269.1 → NP_001319330.1  Mannose-6-phosphate isomerase, type I [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q67YT4, Q9FVM3, Q9FZH5
      UniProtKB/TrEMBL
      A0A178WK67, A0A5S9WQH3
      Conserved Domains (1) summary
      PLN02288
      Location:22 → 419
      PLN02288; mannose-6-phosphate isomerase

    2. NM_105377.5 → NP_176878.1  Mannose-6-phosphate isomerase, type I [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_176878.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q67YT4, Q9FVM3, Q9FZH5
      UniProtKB/TrEMBL
      A0A178WK67, A0A5S9WQH3
      Conserved Domains (1) summary
      PLN02288
      Location:22 → 419
      PLN02288; mannose-6-phosphate isomerase

    3. NM_001334270.1 → NP_001321710.1  Mannose-6-phosphate isomerase, type I [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ARS3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FZH5.1

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