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    ILA ILITYHIA [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842787, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ILA
    Official Full Name
    ILITYHIA
    Primary source
    TAIR:AT1G64790
    Locus tag
    AT1G64790
    See related
    Araport:AT1G64790
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F13O11.35; F13O11_35; ILITHYIA
    Summary
    ILITHYIA (ILA) is a HEAT repeat protein involved in plant immunity. The gene is also involved in systemic acquired resistance induced by P. syringae expressing avrRps4. Loss-of-function mutants of ILA caused pleiotropic defects in the mutant plants. The mutant plants are smaller in size and the leaves are serrated and yellow to light green in color. Required for bacterium-triggered stomatal closure.
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    Genomic context

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    See ILA in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    62
    Sequence:
    Chromosome: 1; NC_003070.9 (24064822..24083428, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene NDH-dependent cyclic electron flow 1 Neighboring gene ammonium transporter 1;2 Neighboring gene uncharacterized protein Neighboring gene DNA binding / transcription factor Neighboring gene APO RNA-binding protein (DUF794)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis nonresponding to oxylipins locus NOXY7 encodes a yeast GCN1 homolog that mediates noncanonical translation regulation and stress adaptation. Izquierdo Y, et al. Plant Cell Environ, 2018 Jun. PMID 29499090
    2. The HEAT repeat protein ILITYHIA is required for plant immunity. Monaghan J, et al. Plant Cell Physiol, 2010 May. PMID 20360018
    3. Arabidopsis ILITHYIA protein is necessary for proper chloroplast biogenesis and root development independent of eIF2α phosphorylation. Faus I, et al. J Plant Physiol, 2018 May-Jun. PMID 29680783
    4. Analysis of the Arabidopsis cytosolic proteome highlights subcellular partitioning of central plant metabolism. Ito J, et al. J Proteome Res, 2011 Apr 1. PMID 21166475
    5. Advanced proteomic analyses yield a deep catalog of ubiquitylation targets in Arabidopsis. Kim DY, et al. Plant Cell, 2013 May. PMID 23667124, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NOXY7/GCN1 but not GCN2 regulates adaptation to mitochondrial dysfunction, high boron concentration, and activation of plant immunity to infection by Pseudomonas syringae pv tomato.[NOXY7]
      Title: Arabidopsis nonresponding to oxylipins locus NOXY7 encodes a yeast GCN1 homolog that mediates noncanonical translation regulation and stress adaptation.
    2. Although both ILA and GCN2 genes are necessary to mediate eIF2alpha phosphorylation upon treatments with the aromatic amino acid biosynthesis inhibitor glyphosate, their mutants develop distinct root and chloroplast phenotypes.
      Title: Arabidopsis ILITHYIA protein is necessary for proper chloroplast biogenesis and root development independent of eIF2α phosphorylation.
    3. ILITYHIA(ILA) functions in immunity against bacterial infection. [ILA]
      Title: The HEAT repeat protein ILITYHIA is required for plant immunity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001198384.1

    Gene Ontology Provided by TAIR

    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in induced systemic resistance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within systemic acquired resistance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    ILITYHIA
    NP_001185313.1
    • ILITHYIA (ILA); FUNCTIONS IN: binding; INVOLVED IN: systemic acquired resistance, defense response to bacterium; LOCATED IN: cytosol, nucleus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: HEAT (InterPro:IPR000357), Armadillo-like helical (InterPro:IPR011989), HEAT, type 2 (InterPro:IPR021133), Armadillo-type fold (InterPro:IPR016024).
    NP_176659.6
    • ILITHYIA (ILA); FUNCTIONS IN: binding; INVOLVED IN: systemic acquired resistance, defense response to bacterium; LOCATED IN: cytosol, nucleus, membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: HEAT (InterPro:IPR000357), Armadillo-like helical (InterPro:IPR011989), HEAT, type 2 (InterPro:IPR021133), Armadillo-type fold (InterPro:IPR016024); Has 3576 Blast hits to 2493 proteins in 284 species: Archae - 50; Bacteria - 199; Metazoa - 1336; Fungi - 986; Plants - 555; Viruses - 13; Other Eukaryotes - 437 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      24064822..24083428 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105153.8 → NP_176659.6  ILITYHIA [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_176659.6

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W5M3, A0A654EWQ2
      Conserved Domains (6) summary
      COG5181
      Location:1861 → 2526
      HSH155; U2 snRNP spliceosome subunit [RNA processing and modification]
      cd00020
      Location:2453 → 2562
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam12074
      Location:344 → 689
      DUF3554; Domain of unknown function (DUF3554)
      pfam13513
      Location:2268 → 2322
      HEAT_EZ; HEAT-like repeat
      pfam13646
      Location:1442 → 1538
      HEAT_2; HEAT repeats
      sd00044
      Location:1865 → 1893
      HEAT; HEAT repeat [structural motif]

    2. NM_001334178.1 → NP_001322207.1  ILITYHIA [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W5M3, A0A1P8AT97, A0A654EWQ2

    3. NM_001198384.1 → NP_001185313.1  ILITYHIA [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185313.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4I893, F4I894, Q9XIR5
      UniProtKB/TrEMBL
      A0A178W5M3, A0A654EWQ2
      Conserved Domains (5) summary
      COG5181
      Location:1947 → 2612
      HSH155; U2 snRNP spliceosome subunit [RNA processing and modification]
      cd00020
      Location:2539 → 2648
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam12074
      Location:463 → 808
      DUF3554; Domain of unknown function (DUF3554)
      pfam13513
      Location:2354 → 2408
      HEAT_EZ; HEAT-like repeat
      sd00044
      Location:1951 → 1979
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4I893.1

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