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    FAB1D FORMS APLOID AND BINUCLEATE CELLS 1A [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 840326, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FAB1D
    Official Full Name
    FORMS APLOID AND BINUCLEATE CELLS 1A
    Primary source
    TAIR:AT1G34260
    Locus tag
    AT1G34260
    See related
    Araport:AT1G34260
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F23M19.8; F23M19_8; FORMS APLOID AND BINUCLEATE CELLS 1A
    Summary
    Encodes a protein that is predicted to act as a phosphatidylinositol-3P 5-kinase, but, because it lacks a FYVE domain, it is unlikely to be efficiently targeted to membranes containing the porposed phosphatidylinositol-3P substrate. Therefore, its molecular function remains unknown.
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    Genomic context

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    See FAB1D in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    14
    Sequence:
    Chromosome: 1; NC_003070.9 (12485318..12492207)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Putative membrane lipoprotein Neighboring gene pseudo Neighboring gene Exostosin family protein Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of FAB1 phosphatidylinositol kinases in Arabidopsis pollen tube growth and fertilization. Serrazina S, et al. New Phytol, 2014 Aug. PMID 24807078
    2. Rapid structural changes and acidification of guard cell vacuoles during stomatal closure require phosphatidylinositol 3,5-bisphosphate. Bak G, et al. Plant Cell, 2013 Jun. PMID 23757398, Free PMC Article
    3. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The function of the Arabidopsis genes encoding FAB1B and FAB1D, both highly expressed in pollen, were investigated.
      Title: Characterization of FAB1 phosphatidylinositol kinases in Arabidopsis pollen tube growth and fertilization.
    2. Data indicate that single and double mutants of phosphatidylinositol 3-phosphate 5-kinases (PI3P5Ks) FAB1A, FAB1B, FAB1C and FAB1D exhibited slow stomatal closure upon ABA treatment.
      Title: Rapid structural changes and acidification of guard cell vacuoles during stomatal closure require phosphatidylinositol 3,5-bisphosphate.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_001333092.1
    NM_001333094.1
    NM_103148.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-phosphate 5-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphatidylinositol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    FORMS APLOID AND BINUCLEATE CELLS 1A
    NP_001319143.1
    • FORMS APLOID AND BINUCLEATE CELLS 1A (FAB1D); FUNCTIONS IN: 1-phosphatidylinositol-4-phosphate 5-kinase activity, phosphatidylinositol phosphate kinase activity, ATP binding; INVOLVED IN: phosphatidylinositol metabolic process, cellular protein metabolic process; LOCATED IN: cellular_component unknown; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Chaperonin Cpn60/TCP-1 (InterPro:IPR002423), Phosphatidylinositol-4-phosphate 5-kinase, core (InterPro:IPR002498); BEST Arabidopsis thaliana protein match is: FORMS APLOID AND BINUCLEATE CELLS 1C (TAIR:AT1G71010.1); Has 3115 Blast hits to 2757 proteins in 368 species: Archae - 419; Bacteria - 0; Metazoa - 983; Fungi - 610; Plants - 538; Viruses - 0; Other Eukaryotes - 565 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      12485318..12492207
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001333093.1 → NP_001321920.1  FORMS APLOID AND BINUCLEATE CELLS 1A [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XID0
      UniProtKB/TrEMBL
      A0A178WIJ4
      Conserved Domains (2) summary
      cd03334
      Location:161 → 429
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd17300
      Location:1180 → 1443
      PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins

    2. NM_001333092.1 → NP_001319143.1  FORMS APLOID AND BINUCLEATE CELLS 1A [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XID0
      UniProtKB/TrEMBL
      A0A178WIJ4
      Conserved Domains (2) summary
      cd03334
      Location:161 → 429
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd17300
      Location:1180 → 1443
      PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins

    3. NM_103148.4 → NP_174686.1  FORMS APLOID AND BINUCLEATE CELLS 1A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_174686.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XID0
      UniProtKB/TrEMBL
      A0A178WIJ4
      Conserved Domains (2) summary
      cd03334
      Location:161 → 429
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd17300
      Location:1180 → 1443
      PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins

    4. NM_001333094.1 → NP_001321919.1  FORMS APLOID AND BINUCLEATE CELLS 1A [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WIJ4, A0A1P8ASD3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XID0.1

    Gene LinkOut

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