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    SRD2 snRNA activating complex family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839756, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SRD2
    Official Full Name
    snRNA activating complex family protein
    Primary source
    TAIR:AT1G28560
    Locus tag
    AT1G28560
    See related
    Araport:AT1G28560
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F3M18.1; SHOOT REDIFFERENTIATION DEFECTIVE 2
    Summary
    Encodes a protein similar to human SNAP50. Mutants display different temperature sensitivities in the dedifferentiation of cells from different organs. Mutation inhibits the dedifferentiation-associated accumulation of U-snRNAs and some other small RNA species encoded by independent-type genes carrying the USE and TATA box. Required for the elevation of cell proliferation competence in hypocotyl dedifferentiation.
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    Genomic context

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    See SRD2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    13
    Sequence:
    Chromosome: 1; NC_003070.9 (10038029..10041544, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene vascular plant one zinc finger protein Neighboring gene deneddylase Neighboring gene uncharacterized protein Neighboring gene RAB GTPase homolog A1I Neighboring gene SGNH hydrolase-type esterase superfamily protein Neighboring gene GDSL-like Lipase/Acylhydrolase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Particular significance of SRD2-dependent snRNA accumulation in polarized pattern generation during lateral root development of Arabidopsis. Ohtani M, et al. Plant Cell Physiol, 2010 Dec. PMID 20965997
    2. Differential requirement for the function of SRD2, an snRNA transcription activator, in various stages of plant development. Ohtani M, et al. Plant Mol Biol, 2008 Feb. PMID 18064403
    3. Involvement of SRD2-mediated activation of snRNA transcription in the control of cell proliferation competence in Arabidopsis. Ohtani M, et al. Plant J, 2005 Aug. PMID 16098103
    4. Isolation of Temperature-Sensitive Mutants of Arabidopsis thaliana That Are Defective in the Redifferentiation of Shoots. Yasutani I, et al. Plant Physiol, 1994 Jul. PMID 12232244, Free PMC Article
    5. Organogenic responses in tissue culture of srd mutants of Arabidopsis thaliana. Ozawa S, et al. Development, 1998 Jan. PMID 9389671

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SRD2 function is particularly important for expression of PINs in polarized pattern generation during the development of lateral root primordia.
      Title: Particular significance of SRD2-dependent snRNA accumulation in polarized pattern generation during lateral root development of Arabidopsis.
    2. In mature plants, SRD2 was highly expressed in developing leaves and flowers as well as apical meristems, and mutations in the SRD2 gene interfered with many, but not all, aspects of development in the regions that showed strong expression of SRD2.
      Title: Differential requirement for the function of SRD2, an snRNA transcription activator, in various stages of plant development.
    3. The SRD2 protein functions in the upregulation of transcription of snRNA genes, the promoters of which contain the upstream sequence element, to elevate cell proliferation competence. [SRD2]
      Title: Involvement of SRD2-mediated activation of snRNA transcription in the control of cell proliferation competence in Arabidopsis.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001123901.2
    NM_001332819.1
    NM_102624.4

    Gene Ontology Provided by TAIR

    Process Evidence Code Pubs
    involved_in auxin polar transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell cycle switching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell dedifferentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to auxin stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to cytokinin stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in lateral root formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in longitudinal axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meristem initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within plant organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in radial axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within snRNA transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in snRNA transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    snRNA activating complex family protein
    NP_001117373.2
    • SHOOT REDIFFERENTIATION DEFECTIVE 2 (SRD2); FUNCTIONS IN: DNA binding; INVOLVED IN: snRNA transcription, organ morphogenesis; LOCATED IN: nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: snRNA-activating protein complex, subunit 3, C-terminal (InterPro:IPR022042); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_174178.2
    • SHOOT REDIFFERENTIATION DEFECTIVE 2 (SRD2); CONTAINS InterPro DOMAIN/s: snRNA-activating protein complex, subunit 3, C-terminal (InterPro:IPR022042); Has 243 Blast hits to 241 proteins in 113 species: Archae - 0; Bacteria - 0; Metazoa - 135; Fungi - 2; Plants - 44; Viruses - 0; Other Eukaryotes - 62 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      10038029..10041544 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_102624.4 → NP_174178.2  snRNA activating complex family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_174178.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4HY74, Q8L627, Q9S7F0
      Conserved Domains (1) summary
      pfam12251
      Location:157 → 371
      zf-SNAP50_C; snRNA-activating protein of 50kDa MW C terminal

    2. NM_001332819.1 → NP_001321583.1  snRNA activating complex family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W5F5, A0A1P8ARE1, A0A654EIT8
      Conserved Domains (1) summary
      pfam12251
      Location:244 → 458
      zf-SNAP50_C; snRNA-activating protein of 50kDa MW C terminal

    3. NM_001123901.2 → NP_001117373.2  snRNA activating complex family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001117373.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8L627
      Conserved Domains (1) summary
      pfam12251
      Location:168 → 382
      zf-SNAP50_C; snRNA-activating protein of 50kDa MW C terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8L627.1

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