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    avtA valine--pyruvate aminotransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948087, updated on 10-Oct-2024

    Summary

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    Official Symbol
    avtA
    Official Full Name
    valine--pyruvate aminotransferase
    Primary source
    ECOCYC:EG10107
    Locus tag
    b3572
    See related
    ASAP:ABE-0011671
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3561
    Summary
    Valine-pyruvate aminotransferase (transaminase C) catalyzes several interconversions involved in amino acid syntheses. [More information is available at EcoCyc: EG10107].
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    Genomic context

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    Sequence:
    NC_000913.3 (3739705..3740958)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative glycoside hydrolase Bax Neighboring gene putative translational regulatory protein BaxL Neighboring gene alpha-amylase Neighboring gene putative electron transport protein YsaA Neighboring gene DNA-binding transcriptional repressor PlaR

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of an avtA::Mu d1(Ap lac) mutant: metabolic role of transaminase C. Whalen WA, et al. J Bacteriol, 1982 May. PMID 7040341, Free PMC Article
    2. Gratuitous repression of avtA in Escherichia coli and Salmonella typhimurium. Whalen WA, et al. J Bacteriol, 1984 May. PMID 6373721, Free PMC Article
    3. Regulation of transaminase C synthesis in Escherichia coli: conditional leucine auxotrophy. McGilvray D, et al. J Bacteriol, 1974 Nov. PMID 4616947, Free PMC Article
    4. Induction kinetics of the L-arabinose operon of Escherichia coli. Schleif R, et al. J Bacteriol, 1973 Jul. PMID 4577756, Free PMC Article
    5. Rapid sequencing of cloned DNA using a transposon for bidirectional priming: sequence of the Escherichia coli K-12 avtA gene. Liu L, et al. Nucleic Acids Res, 1987 Nov 25. PMID 2825136, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural analysis and mutant growth properties reveal distinctive enzymatic and cellular roles for the three major L-alanine transaminases of Escherichia coli.
      Title: Structural analysis and mutant growth properties reveal distinctive enzymatic and cellular roles for the three major L-alanine transaminases of Escherichia coli.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transaminase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables valine-pyruvate transaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables valine-pyruvate transaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables valine-pyruvate transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in D-alanine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within L-alanine biosynthetic process EXP
    Inferred from Experiment
    more info
    		 PubMed 
    acts_upstream_of_or_within L-valine biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in alpha-amino acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    valine--pyruvate aminotransferase
    YP_026231.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3739705..3740958
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_026231.1 valine--pyruvate aminotransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for YP_026231.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A444RDL5, A0A7A6RUG8, A0A828P5W4, A0AAN5JDF9, A0AAQ2LS27
      Conserved Domains (1) summary
      PRK09440
      Location:1 → 416
      avtA; valine--pyruvate transaminase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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