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    amn AMP nucleosidase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946508, updated on 10-Oct-2024

    Summary

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    Official Symbol
    amn
    Official Full Name
    AMP nucleosidase
    Primary source
    ECOCYC:EG10039
    Locus tag
    b1982
    See related
    ASAP:ABE-0006579
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1977
    Summary
    PhoB regulon (Baek, 2006). [More information is available at EcoGene: EG10039]. AMP nucleosidase is the primary intracellular mechanism for AMP degradation in Escherichia coli. [More information is available at EcoCyc: EG10039].
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    Genomic context

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    Sequence:
    NC_000913.3 (2055061..2056515)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene shikimate:H(+) symporter Neighboring gene putative transcriptional regulator YeeN Neighboring gene tRNA-Asn

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An AMP nucleosidase gene knockout in Escherichia coli elevates intracellular ATP levels and increases cold tolerance. Morrison BA, et al. Biol Lett, 2008 Feb 23. PMID 18029299, Free PMC Article
    2. Structure of Escherichia coli AMP nucleosidase reveals similarity to nucleoside phosphorylases. Zhang Y, et al. Structure, 2004 Aug. PMID 15296732
    3. Mutagenic analysis of AMP nucleosidase from Escherichia coli. Deletion of a region similar to AMP deaminase and peptide characterization by mass spectrometry. Kvalnes-Krick K, et al. J Biol Chem, 1993 Apr 25. PMID 8473316
    4. Unexpected sequence similarity between nucleosidases and phosphoribosyltransferases of different specificity. Mushegian AR, et al. Protein Sci, 1994 Jul. PMID 7920254, Free PMC Article
    5. Adenylate degradation in Escherichia coli. The role of AMP nucleosidase and properties of the purified enzyme. Leung HB, et al. J Biol Chem, 1980 Nov 25. PMID 7000783

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The relationship between cold temperature survivability and elevated intracellular ATP was studied in E. coli with a deletion at this gene locus.
      Title: An AMP nucleosidase gene knockout in Escherichia coli elevates intracellular ATP levels and increases cold tolerance.
    2. N-terminus verified by Edman degradation on complete protein
      Title: Structure and regulation of the AMP nucleosidase gene (amn) from Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables AMP nucleosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables AMP nucleosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in AMP metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in AMP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleoside metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    AMP nucleosidase
    NP_416489.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2055061..2056515
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416489.1 AMP nucleosidase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416489.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7ELA6, A0AAN3KNS7
      Conserved Domains (1) summary
      PRK08292
      Location:1 → 484
      PRK08292; AMP nucleosidase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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