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    RAB33A RAB33A, member RAS oncogene family [ Homo sapiens (human) ]

    Gene ID: 9363, updated on 2-Nov-2024

    Summary

    Official Symbol
    RAB33Aprovided by HGNC
    Official Full Name
    RAB33A, member RAS oncogene familyprovided by HGNC
    Primary source
    HGNC:HGNC:9773
    See related
    Ensembl:ENSG00000134594 MIM:300333; AllianceGenome:HGNC:9773
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RabS10
    Summary
    The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. It is GTP-binding protein and may be involved in vesicle transport. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in brain (RPKM 10.9), lymph node (RPKM 3.6) and 7 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See RAB33A in Genome Data Viewer
    Location:
    Xq26.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (130110623..130184870)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (128429426..128503675)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (129305936..129318844)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373335 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20979 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29931 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20980 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20981 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20982 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20983 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20984 Neighboring gene UTP14A small subunit processome component Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:129086824-129087554 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:129093062-129093562 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20985 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:129117440-129117676 Neighboring gene BCL6 corepressor like 1 Neighboring gene uncharacterized LOC124905216 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29932 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:129159157-129159656 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20986 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20987 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20988 Neighboring gene Sharpr-MPRA regulatory region 15346 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29934 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29936 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29937 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20989 Neighboring gene Sharpr-MPRA regulatory region 9263 Neighboring gene E74 like ETS transcription factor 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20990 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20991 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20992 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20993 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20994 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29938 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20995 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:129255011-129255220 Neighboring gene MED14-independent group 3 enhancer GRCh37_chrX:129280263-129281462 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29939 Neighboring gene apoptosis inducing factor mitochondria associated 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29940 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20996 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20997 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:129305519-129306473 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29941 Neighboring gene zinc finger protein 280C Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20998 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:129413936-129414929 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:129414930-129415922 Neighboring gene RNA, U6 small nuclear 1130, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC1488

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Rab protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in antigen processing and presentation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ras-related protein Rab-33A
    Names
    Small GTP-binding protein S10

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012558.1 RefSeqGene

      Range
      5164..18072
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_004794.3NP_004785.1  ras-related protein Rab-33A

      See identical proteins and their annotated locations for NP_004785.1

      Status: REVIEWED

      Source sequence(s)
      BC001157
      Consensus CDS
      CCDS14621.1
      UniProtKB/Swiss-Prot
      Q14088, Q5JUZ6, Q92465
      Related
      ENSP00000257017.4, ENST00000257017.5
      Conserved Domains (1) summary
      cd04115
      Location:35204
      Rab33B_Rab33A; Rab GTPase family 33 includes Rab33A and Rab33B

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      130110623..130184870
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017029963.3XP_016885452.1  ras-related protein Rab-33A isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      128429426..128503675
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328134.1XP_054184109.1  ras-related protein Rab-33A isoform X1