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    RGLG4 Ca(2)-dependent phospholipid-binding protein (Copine) family [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 844276, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RGLG4
    Official Full Name
    Ca(2)-dependent phospholipid-binding protein (Copine) family
    Primary source
    TAIR:AT1G79380
    Locus tag
    AT1G79380
    See related
    Araport:AT1G79380
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    RING DOMAIN LIGASE 4; T8K14.20; T8K14_20
    Summary
    Encodes a ubiquitin ligase that is an essential upstream modulator of JA signaling in response to various stimuli.
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    Genomic context

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    See RGLG4 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    11
    Sequence:
    Chromosome: 1; NC_003070.9 (29860491..29863316)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene organic cation/carnitine transporter 2 Neighboring gene cytochrome P450, family 79, subfamily C, polypeptide 1 Neighboring gene centrosomal protein Neighboring gene cation/H+ exchanger 2 Neighboring gene organic cation/carnitine transporter5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hijacking of the jasmonate pathway by the mycotoxin fumonisin B1 (FB1) to initiate programmed cell death in Arabidopsis is modulated by RGLG3 and RGLG4. Zhang X, et al. J Exp Bot, 2015 May. PMID 25788731, Free PMC Article
    2. Two novel RING-type ubiquitin ligases, RGLG3 and RGLG4, are essential for jasmonate-mediated responses in Arabidopsis. Zhang X, et al. Plant Physiol, 2012 Oct. PMID 22898498, Free PMC Article
    3. The Arabidopsis Iron-Sulfur Protein GRXS17 is a Target of the Ubiquitin E3 Ligases RGLG3 and RGLG4. Nagels Durand A, et al. Plant Cell Physiol, 2016 Sep. PMID 27497447
    4. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article
    5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GRXS17 is ubiquitinated and degraded in a proteasome-dependent manner by RGLG3 and RGLG4.
      Title: The Arabidopsis Iron-Sulfur Protein GRXS17 is a Target of the Ubiquitin E3 Ligases RGLG3 and RGLG4.
    2. RGLG3 and RGLG4 have coordinated and positive roles in mycotoxin fumonisin B1 (FB1)-elicited programmed cell death. [RGLG4]
      Title: Hijacking of the jasmonate pathway by the mycotoxin fumonisin B1 (FB1) to initiate programmed cell death in Arabidopsis is modulated by RGLG3 and RGLG4.
    3. RGLG3 and RGLG4 are essential upstream modulators of jasmonate signaling in response to various stimuli.
      Title: Two novel RING-type ubiquitin ligases, RGLG3 and RGLG4, are essential for jasmonate-mediated responses in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_106586.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within jasmonic acid mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to wounding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ca(2)-dependent phospholipid-binding protein (Copine) family
    NP_565206.1
    • Ca(2)-dependent phospholipid-binding protein (Copine) family; FUNCTIONS IN: zinc ion binding; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR001841), Copine (InterPro:IPR010734), von Willebrand factor, type A (InterPro:IPR002035); BEST Arabidopsis thaliana protein match is: RING domain ligase2 (TAIR:AT5G14420.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      29860491..29863316
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_106586.4 → NP_565206.1  Ca(2)-dependent phospholipid-binding protein (Copine) family [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565206.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SAL0
      UniProtKB/TrEMBL
      A0A178W3R7, A0A654EQB6
      Conserved Domains (2) summary
      pfam07002
      Location:102 → 318
      Copine
      cd16729
      Location:357 → 400
      RING-HC_RGLG_plant; RING finger, HC subclass, found in RING domain ligase RGLG1, RGLG2 and similar proteins from plant
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SAL0.1

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