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    MBD7 methyl-CPG-binding domain 7 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836101, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MBD7
    Official Full Name
    methyl-CPG-binding domain 7
    Primary source
    TAIR:AT5G59800
    Locus tag
    AT5G59800
    See related
    Araport:AT5G59800
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA METHYL-CPG-BINDING DOMAIN 7; ATMBD7; methyl-CPG-binding domain 7; MMN10.2; MMN10_2
    Summary
    Protein containing methyl-CpG-binding domain.Has sequence similarity to human MBD proteins. Interacts with arginine methyltransferase 11. (AtPRMT11
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    Genomic context

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    See MBD7 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    6
    Sequence:
    Chromosome: 5; NC_003076.8 (24094359..24096532, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene UPSTREAM OF FLC protein (DUF966) Neighboring gene Subtilase family protein Neighboring gene C2H2-type zinc finger family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The methyl-CpG-binding protein MBD7 facilitates active DNA demethylation to limit DNA hyper-methylation and transcriptional gene silencing. Lang Z, et al. Mol Cell, 2015 Mar 19. PMID 25684209, Free PMC Article
    2. The C-terminal domain of the Arabidopsis AtMBD7 protein confers strong chromatin binding activity. Zemach A, et al. Exp Cell Res, 2009 Dec 10. PMID 19647732
    3. Methyl-CpG-binding domain protein MBD7 is required for active DNA demethylation in Arabidopsis. Wang C, et al. Plant Physiol, 2015 Mar. PMID 25593350, Free PMC Article
    4. The three methyl-CpG-binding domains of AtMBD7 control its subnuclear localization and mobility. Zemach A, et al. J Biol Chem, 2008 Mar 28. PMID 18211904, Free PMC Article
    5. DDM1 binds Arabidopsis methyl-CpG binding domain proteins and affects their subnuclear localization. Zemach A, et al. Plant Cell, 2005 May. PMID 15805479, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MBD7 binds to genomic regions with a high density of CG methylation.MBD7 physically associates with IDM3, and with IDM1 and IDM2 proteins.MBD7 and IDM3 prevent DNA hypermethylation and gene silencing.
      Title: The methyl-CpG-binding protein MBD7 facilitates active DNA demethylation to limit DNA hyper-methylation and transcriptional gene silencing.
    2. MBD7 is required for active DNA demethylation and antisilencing of the genomic loci with high densities of DNA methylation in Arabidopsis.
      Title: Methyl-CpG-binding domain protein MBD7 is required for active DNA demethylation in Arabidopsis.
    3. The C-terminal, StkC motif plays an important role in fastening AtMBD7 to its chromosomal, CpG-methylated sites.
      Title: The C-terminal domain of the Arabidopsis AtMBD7 protein confers strong chromatin binding activity.
    4. poly-MBD proteins can directly affect chromatin structure by inducing intra- and inter-chromatin compaction via bridging over multiple methylated CpG sites
      Title: The three methyl-CpG-binding domains of AtMBD7 control its subnuclear localization and mobility.
    5. The characterization of proteins interacting with MBD7, especially PRMT11, is reported.
      Title: PRMT11: a new Arabidopsis MBD7 protein partner with arginine methyltransferase activity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_125372.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    NOT enables cytosine C-5 DNA demethylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables methyl-CpG binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methyl-CpG binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromocenter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    methyl-CPG-binding domain 7
    NP_200788.1
    • methyl-CPG-binding domain 7 (MBD7); CONTAINS InterPro DOMAIN/s: DNA-binding, integrase-type (InterPro:IPR016177), Methyl-CpG DNA binding (InterPro:IPR001739); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      24094359..24096532 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125372.4 → NP_200788.1  methyl-CPG-binding domain 7 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200788.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FJF4
      UniProtKB/TrEMBL
      A0A178UP18, A0A5S9YG91
      Conserved Domains (2) summary
      cd01396
      Location:176 → 243
      MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
      cl00110
      Location:114 → 156
      MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FJF4.1

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