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    ZEU1 P-loop containing nucleoside triphosphate hydrolases superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836063, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ZEU1
    Official Full Name
    P-loop containing nucleoside triphosphate hydrolases superfamily protein
    Primary source
    TAIR:AT5G59440
    Locus tag
    AT5G59440
    See related
    Araport:AT5G59440
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA THYMIDYLATE KINASE.1; ARABIDOPSIS THALIANA THYMIDYLATE KINASE.2; ATTMPK.1; ATTMPK.2; F2O15.12; F2O15_12; ZEUS1
    Summary
    Encodes thymidylate kinase which exists in two isoforms in plants. The longer variant of 263 amino acids with a N-terminal extension that is required for localization to the mitochondrion. The second isoform of 224 residues is localized to the cytoplasm and nucleoplasm. Peak of expression occurs during G1/S phase transition.
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    Genomic context

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    See ZEU1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    5
    Sequence:
    Chromosome: 5; NC_003076.8 (23971063..23972964)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene OSBP(oxysterol binding protein)-related protein 3C Neighboring gene telomeric repeat binding protein 1 Neighboring gene GRAS family transcription factor Neighboring gene ncRNA Neighboring gene scarecrow-like transcription factor 11 (SCL11)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The first zygotic division in Arabidopsis requires de novo transcription of thymidylate kinase. Ronceret A, et al. Plant J, 2008 Mar. PMID 18036198
    2. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    NM_001085303.1
    NM_125335.4
    NM_180891.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thymidylate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in dTDP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dTTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    P-loop containing nucleoside triphosphate hydrolases superfamily protein
    NP_001078772.1
    • ZEUS1 (ZEU1); FUNCTIONS IN: thymidylate kinase activity, ATP binding; INVOLVED IN: dTDP biosynthetic process; LOCATED IN: nucleoplasm, mitochondrion, cytoplasm; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Thymidylate kinase (InterPro:IPR018094), Thymidylate kinase-like (InterPro:IPR000062), Thymidylate kinase, conserved site (InterPro:IPR018095); Has 5505 Blast hits to 5503 proteins in 2206 species: Archae - 247; Bacteria - 3933; Metazoa - 204; Fungi - 151; Plants - 114; Viruses - 143; Other Eukaryotes - 713 (source: NCBI BLink).
    NP_568907.2
    • ZEUS1 (ZEU1); FUNCTIONS IN: thymidylate kinase activity, ATP binding; INVOLVED IN: dTDP biosynthetic process; LOCATED IN: nucleoplasm, mitochondrion, cytoplasm; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Thymidylate kinase (InterPro:IPR018094), Thymidylate kinase-like (InterPro:IPR000062), Thymidylate kinase, conserved site (InterPro:IPR018095); Has 5466 Blast hits to 5464 proteins in 2193 species: Archae - 247; Bacteria - 3894; Metazoa - 202; Fungi - 154; Plants - 114; Viruses - 142; Other Eukaryotes - 713 (source: NCBI BLink).
    NP_851222.1
    • ZEUS1 (ZEU1); FUNCTIONS IN: thymidylate kinase activity, ATP binding; INVOLVED IN: dTDP biosynthetic process, pyrimidine deoxyribonucleoside interconversion, anaerobic respiration; LOCATED IN: nucleoplasm, mitochondrion, cytoplasm; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Thymidylate kinase (InterPro:IPR018094), Thymidylate kinase-like (InterPro:IPR000062), Thymidylate kinase, conserved site (InterPro:IPR018095); Has 5519 Blast hits to 5517 proteins in 2216 species: Archae - 247; Bacteria - 3946; Metazoa - 202; Fungi - 154; Plants - 114; Viruses - 143; Other Eukaryotes - 713 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      23971063..23972964
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125335.4 → NP_568907.2  P-loop containing nucleoside triphosphate hydrolases superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568907.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UQB6, A0A5S9YHT7
      Conserved Domains (2) summary
      PLN02924
      Location:5 → 224
      PLN02924; thymidylate kinase
      pfam02223
      Location:25 → 201
      Thymidylate_kin; Thymidylate kinase

    2. NM_180891.4 → NP_851222.1  P-loop containing nucleoside triphosphate hydrolases superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851222.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0NAB2, A2P2R9, Q0WW55, Q8LEB4, Q93ZP0
      UniProtKB/TrEMBL
      A0A178UPB2, A0A5S9YHT7
      Conserved Domains (1) summary
      PLN02924
      Location:44 → 263
      PLN02924; thymidylate kinase

    3. NM_001085303.1 → NP_001078772.1  P-loop containing nucleoside triphosphate hydrolases superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078772.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9YHT7, A0A654GCG9, F4KJ62
      Conserved Domains (1) summary
      PLN02924
      Location:52 → 271
      PLN02924; thymidylate kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0WW55.1

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