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    CDF1 cell growth defect factor-like protein (DUF3353) [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832368, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CDF1
    Official Full Name
    cell growth defect factor-like protein (DUF3353)
    Primary source
    TAIR:AT5G23040
    Locus tag
    AT5G23040
    See related
    Araport:AT5G23040
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CELL GROWTH DEFECT FACTOR 1; CHAPERONE-LIKE PROTEIN OF POR1; CPP1; MYJ24.3; MYJ24_3
    Summary
    Cell growth defect factor 1. Causes Bax mediated lethality in yeast by generating reactive oxygen species and this effect is suppressed by AtBI-1.
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    Genomic context

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    See CDF1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    6
    Sequence:
    Chromosome: 5; NC_003076.8 (7729171..7731200, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene 2-isopropylmalate synthase 2 Neighboring gene tetraspanin12 Neighboring gene Putative membrane lipoprotein Neighboring gene acyl-activating enzyme 17 Neighboring gene calcium sensing receptor

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Plastidic protein Cdf1 is essential in Arabidopsis embryogenesis. Kawai-Yamada M, et al. Planta, 2014 Jan. PMID 24097264
    2. Cell growth defect factor 1 is crucial for the plastid import of NADPH:protochlorophyllide oxidoreductase A in Arabidopsis thaliana. Reinbothe S, et al. Proc Natl Acad Sci U S A, 2015 May 5. PMID 25901327, Free PMC Article
    3. Cell growth defect factor1/chaperone-like protein of POR1 plays a role in stabilization of light-dependent protochlorophyllide oxidoreductase in Nicotiana benthamiana and Arabidopsis. Lee JY, et al. Plant Cell, 2013 Oct. PMID 24151298, Free PMC Article
    4. A novel Arabidopsis gene causes Bax-like lethality in Saccharomyces cerevisiae. Kawai-Yamada M, et al. J Biol Chem, 2005 Nov 25. PMID 16192270
    5. Proteomic study of the Arabidopsis thaliana chloroplastic envelope membrane utilizing alternatives to traditional two-dimensional electrophoresis. Froehlich JE, et al. J Proteome Res, 2003 Jul-Aug. PMID 12938931

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cell growth defect factor 1 has a critical role in plastid import of NADPH: protochlorophyllide oxidoreductase A in Arabidopsis thaliana
      Title: Cell growth defect factor 1 is crucial for the plastid import of NADPH:protochlorophyllide oxidoreductase A in Arabidopsis thaliana.
    2. Cdf1 was essential for Arabidopsis embryogenesis.
      Title: Plastidic protein Cdf1 is essential in Arabidopsis embryogenesis.
    3. chaperone-like protein of POR1 (CPP1), plays a crucial role in chlorophyll synthesis and chloroplast biogenesis by regulating the stability and function of protochlorophyllide oxidoreductase
      Title: Cell growth defect factor1/chaperone-like protein of POR1 plays a role in stabilization of light-dependent protochlorophyllide oxidoreductase in Nicotiana benthamiana and Arabidopsis.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_001343786.1
    NM_122210.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein folding chaperone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chaperone-mediated protein folding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in chloroplast organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in de-etiolation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of protein import into chloroplast stroma IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast stroma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast thylakoid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plastid HDA PubMed 
    located_in plastid thylakoid membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cell growth defect factor-like protein (DUF3353)
    NP_197695.1
    • CELL GROWTH DEFECT FACTOR 1 (CDF1); INVOLVED IN: cell death; LOCATED IN: mitochondrion, chloroplast, chloroplast envelope; EXPRESSED IN: shoot, flower, leaf; CONTAINS InterPro DOMAIN/s: Protein of unknown function DUF3353 (InterPro:IPR021788); BEST Arabidopsis thaliana protein match is: Protein of unknown function (DUF3353) (TAIR:AT3G51140.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      7729171..7731200 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_122210.5 → NP_197695.1  cell growth defect factor-like protein (DUF3353) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197695.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FN50
      UniProtKB/TrEMBL
      A0A178UEX5, A0A5S9Y6F1
      Conserved Domains (1) summary
      pfam11833
      Location:79 → 257
      CPP1-like; Protein CHAPERONE-LIKE PROTEIN OF POR1-like

    2. NM_001343786.1 → NP_001331796.1  cell growth defect factor-like protein (DUF3353) [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FN50
      UniProtKB/TrEMBL
      A0A178UEX5, A0A5S9Y6F1
      Conserved Domains (1) summary
      pfam11833
      Location:79 → 257
      CPP1-like; Protein CHAPERONE-LIKE PROTEIN OF POR1-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FN50.1

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