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    ENDO5 endonuclease 5 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828246, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ENDO5
    Official Full Name
    endonuclease 5
    Primary source
    TAIR:AT4G21600
    Locus tag
    AT4G21600
    See related
    Araport:AT4G21600
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    endonuclease 5; F17L22.60
    Summary
    Encodes a protein with mismatch-specific endonuclease activity with a preference for T/G, A/G, and G/G of single base mismatches. It also has the ability to cleave indel types of mismatches (heteroduplexes with loops).
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    Genomic context

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    See ENDO5 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    10
    Sequence:
    Chromosome: 4; NC_003075.7 (11484981..11487535)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene endonuclease 3 Neighboring gene ncRNA Neighboring gene miscRNA Neighboring gene lsd one like 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The plant s1-like nuclease family has evolved a highly diverse range of catalytic capabilities. Lesniewicz K, et al. Plant Cell Physiol, 2013 Jul. PMID 23620482
    2. Characterization of Arabidopsis thaliana mismatch specific endonucleases: application to mutation discovery by TILLING in pea. Triques K, et al. Plant J, 2007 Sep. PMID 17651368
    3. Advanced proteomic analyses yield a deep catalog of ubiquitylation targets in Arabidopsis. Kim DY, et al. Plant Cell, 2013 May. PMID 23667124, Free PMC Article
    4. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that five S1-like nucleases have been named as ENDO1 (BFN1, AT1G11190), ENDO2 (AT1G68290), ENDO3 (AT4G21590), ENDO4 (AT4G21585) and ENDO5 (AT4G21600).
      Title: The plant s1-like nuclease family has evolved a highly diverse range of catalytic capabilities.
    2. ENDO5 is a root specific, Zn2+-dependent nuclease which degrades ssDNA and RNA at neutral pH
      Title: The plant s1-like nuclease family has evolved a highly diverse range of catalytic capabilities.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_118280.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables RNA endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables T/G mismatch-specific endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA endodeoxyribonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within DNA metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    endonuclease 5
    NP_567631.1
    • endonuclease 5 (ENDO5); FUNCTIONS IN: T/G mismatch-specific endonuclease activity, single-stranded DNA specific endodeoxyribonuclease activity, endonuclease activity, nucleic acid binding; INVOLVED IN: DNA catabolic process; LOCATED IN: endomembrane system; EXPRESSED IN: 8 plant structures; EXPRESSED DURING: F mature embryo stage, petal differentiation and expansion stage, E expanded cotyledon stage, D bilateral stage; CONTAINS InterPro DOMAIN/s: Phospholipase C/P1 nuclease, core (InterPro:IPR008947), S1/P1 nuclease (InterPro:IPR003154); BEST Arabidopsis thaliana protein match is: endonuclease 4 (TAIR:AT4G21585.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      11484981..11487535
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118280.2 → NP_567631.1  endonuclease 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567631.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4JJL3, O65425, Q8LA68
      UniProtKB/TrEMBL
      A0A5S9XV62, A0A654FRK8
      Conserved Domains (1) summary
      pfam02265
      Location:21 → 288
      S1-P1_nuclease; S1/P1 Nuclease
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4JJL3.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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