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    NTMC2T4 Calcium-dependent lipid-binding (CaLB domain) family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 825277, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NTMC2T4
    Official Full Name
    Calcium-dependent lipid-binding (CaLB domain) family protein
    Primary source
    TAIR:AT3G61050
    Locus tag
    AT3G61050
    See related
    Araport:AT3G61050
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtCLB; calcium-dependent lipid-binding protein; NTMC2TYPE4
    Summary
    Encodes a novel transcriptional regulator, a calcium-dependent lipid-binding protein containing a C2 domain, that binds specifically to the promoter of THAS1 (thalianol synthase 1). It can bind ceramide and is involved in drought and salt tolerance.
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    Genomic context

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    See NTMC2T4 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    13
    Sequence:
    Chromosome: 3; NC_003074.8 (22597216..22601412)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Cytochrome P450 superfamily protein Neighboring gene cytochrome P450, family 76, subfamily C, polypeptide 7 Neighboring gene phloem protein 2-A13 Neighboring gene peroxin 11E Neighboring gene Protein kinase superfamily protein Neighboring gene Putative endonuclease or glycosyl hydrolase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and Initial Characterization of the Effectors of an Anther Smut Fungus and Potential Host Target Proteins. Kuppireddy VS, et al. Int J Mol Sci, 2017 Nov 22. PMID 29165363, Free PMC Article
    2. Structural and functional relationships between plasmodesmata and plant endoplasmic reticulum-plasma membrane contact sites consisting of three synaptotagmins. Ishikawa K, et al. New Phytol, 2020 May. PMID 31869440
    3. Arabidopsis thaliana calcium-dependent lipid-binding protein (AtCLB): a novel repressor of abiotic stress response. de Silva K, et al. J Exp Bot, 2011 May. PMID 21252258
    4. Novel Aquaporin Regulatory Mechanisms Revealed by Interactomics. Bellati J, et al. Mol Cell Proteomics, 2016 Nov. PMID 27609422, Free PMC Article
    5. A high content in lipid-modified peripheral proteins and integral receptor kinases features in the arabidopsis plasma membrane proteome. Marmagne A, et al. Mol Cell Proteomics, 2007 Nov. PMID 17644812

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001035831.2
    NM_115969.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ceramide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive gravitropism IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to water deprivation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Calcium-dependent lipid-binding (CaLB domain) family protein
    NP_001030908.1
    • NTMC2T4; FUNCTIONS IN: lipid binding; INVOLVED IN: biological_process unknown; LOCATED IN: plasma membrane; EXPRESSED IN: male gametophyte, cultured cell, callus, pollen tube; EXPRESSED DURING: M germinated pollen stage; CONTAINS InterPro DOMAIN/s: C2 membrane targeting protein (InterPro:IPR018029), C2 calcium/lipid-binding domain, CaLB (InterPro:IPR008973), C2 region (InterPro:IPR020477), C2 calcium-dependent membrane targeting (InterPro:IPR000008); BEST Arabidopsis thaliana protein match is: Calcium-dependent lipid-binding (CaLB domain) family protein (TAIR:AT3G61030.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_191664.1
    • NTMC2T4; FUNCTIONS IN: lipid binding; INVOLVED IN: biological_process unknown; LOCATED IN: plasma membrane; EXPRESSED IN: male gametophyte, cultured cell, callus, pollen tube; EXPRESSED DURING: M germinated pollen stage; CONTAINS InterPro DOMAIN/s: C2 membrane targeting protein (InterPro:IPR018029), C2 calcium/lipid-binding domain, CaLB (InterPro:IPR008973), C2 region (InterPro:IPR020477), C2 calcium-dependent membrane targeting (InterPro:IPR000008); BEST Arabidopsis thaliana protein match is: Calcium-dependent lipid-binding (CaLB domain) family protein (TAIR:AT3G61030.1); Has 7034 Blast hits to 5237 proteins in 360 species: Archae - 8; Bacteria - 265; Metazoa - 4095; Fungi - 909; Plants - 1092; Viruses - 2; Other Eukaryotes - 663 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      22597216..22601412
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001035831.2 → NP_001030908.1  Calcium-dependent lipid-binding (CaLB domain) family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001030908.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P92940, Q9LEX1
      UniProtKB/TrEMBL
      A0A5S9XMN3, A0A654FJN7
      Conserved Domains (1) summary
      COG5038
      Location:2 → 354
      COG5038; Ca2+-dependent lipid-binding protein, contains C2 domain [General function prediction only]

    2. NM_115969.3 → NP_191664.1  Calcium-dependent lipid-binding (CaLB domain) family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191664.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P92940, Q9LEX1
      UniProtKB/TrEMBL
      A0A5S9XMN3, A0A654FJN7
      Conserved Domains (1) summary
      COG5038
      Location:2 → 354
      COG5038; Ca2+-dependent lipid-binding protein, contains C2 domain [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LEX1.1

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