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    MRH2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824652, updated on 22-Aug-2024

    Summary

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    Official Symbol
    MRH2
    Primary source
    Araport:AT3G54870
    Locus tag
    AT3G54870
    See related
    TAIR:AT3G54870
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    Arabidopsis thaliana KINESIN Ungrouped clade; ARK1; ARMADILLO REPEAT-CONTAINING KINESIN 1; AtKINUc; CA-ROP2 ENHANCER 1; CAE1; gene A; MORPHOGENESIS OF ROOT HAIR 2
    Summary
    Armadillo-repeat containing kinesin-related protein. Plays a role during transition to root-hair tip growth.Mutants have short, branched root hairs and an excess of endoplasmic microtubles. Phenotype suggests ARK1 plays a role in modulating microtubule depolymerization during root hair tip growth.
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    Genomic context

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    Location:
    chromosome: 3
    Exon count:
    21
    Sequence:
    Chromosome: 3; NC_003074.8 (20330680..20336866)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene plant U-box 14 Neighboring gene Sec1/munc18-like (SM) proteins superfamily Neighboring gene zinc finger protein Neighboring gene chlorophyll a-b binding protein 6 Neighboring gene CAX interacting protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rapid identification of a natural knockout allele of ARMADILLO REPEAT-CONTAINING KINESIN1 that causes root hair branching by mapping-by-sequencing. Rishmawi L, et al. Plant Physiol, 2014 Nov. PMID 25248719, Free PMC Article
    2. The microtubule plus-end tracking protein ARMADILLO-REPEAT KINESIN1 promotes microtubule catastrophe in Arabidopsis. Eng RC, et al. Plant Cell, 2014 Aug. PMID 25159991, Free PMC Article
    3. Armadillo-repeat kinesin1 interacts with Arabidopsis atlastin RHD3 to move ER with plus-end of microtubules. Sun J, et al. Nat Commun, 2020 Nov 2. PMID 33139737, Free PMC Article
    4. The ARM Domain of ARMADILLO-REPEAT KINESIN 1 is Not Required for Microtubule Catastrophe But Can Negatively Regulate NIMA-RELATED KINASE 6 in Arabidopsis thaliana. Eng RC, et al. Plant Cell Physiol, 2017 Aug 1. PMID 28505371
    5. A class I ADP-ribosylation factor GTPase-activating protein is critical for maintaining directional root hair growth in Arabidopsis. Yoo CM, et al. Plant Physiol, 2008 Aug. PMID 18539780, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Armadillo-repeat kinesin1 interacts with Arabidopsis atlastin RHD3 to move ER with plus-end of microtubules.
      Title: Armadillo-repeat kinesin1 interacts with Arabidopsis atlastin RHD3 to move ER with plus-end of microtubules.
    2. ARK1 and NEK6 function independently in microtubule dynamics and cell morphogenesis.ARK1 does not require its ARM domain to induce microtubule catastrophe.
      Title: The ARM Domain of ARMADILLO-REPEAT KINESIN 1 is Not Required for Microtubule Catastrophe But Can Negatively Regulate NIMA-RELATED KINASE 6 in Arabidopsis thaliana.
    3. ARK1 is associated with microtubule catastrophe in Arabidopsis.
      Title: The microtubule plus-end tracking protein ARMADILLO-REPEAT KINESIN1 promotes microtubule catastrophe in Arabidopsis.
    4. The causative single nucleotide polymorphism changing a splicing site in ARMADILLO REPEAT-CONTAINING KINESIN1.
      Title: Rapid identification of a natural knockout allele of ARMADILLO REPEAT-CONTAINING KINESIN1 that causes root hair branching by mapping-by-sequencing.
    5. ARK1 is a component of a signaling pathway that affects cytoskeletal organization to specify growth orientation in Arabidopsis root hairs.
      Title: A class I ADP-ribosylation factor GTPase-activating protein is critical for maintaining directional root hair growth in Arabidopsis.
    6. the plant-specific kinesin-related protein MRH2 is an important component that controls MT organization and is likely involved in the ROP2 GTPase-controlled coordination of AF and MT during polarized growth of root hairs
      Title: A mutation in MRH2 kinesin enhances the root hair tip growth defect caused by constitutively activated ROP2 small GTPase in Arabidopsis.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_115344.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of microtubule polymerization or depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root hair cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root hair cell tip growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Armadillo/beta-catenin repeat family protein / kinesin motor family protein
    NP_191047.3
    • MORPHOGENESIS OF ROOT HAIR 2 (MRH2); FUNCTIONS IN: microtubule binding, actin binding, microtubule motor activity; INVOLVED IN: root hair cell tip growth, root hair cell differentiation, regulation of microtubule polymerization or depolymerization; LOCATED IN: chloroplast; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 7 growth stages; CONTAINS InterPro DOMAIN/s: Kinesin, motor region, conserved site (InterPro:IPR019821), Armadillo-like helical (InterPro:IPR011989), Armadillo (InterPro:IPR000225), Armadillo-type fold (InterPro:IPR016024), Kinesin, motor domain (InterPro:IPR001752); BEST Arabidopsis thaliana protein match is: armadillo repeat kinesin 3 (TAIR:AT1G12430.1); Has 140801 Blast hits to 75642 proteins in 3085 species: Archae - 1274; Bacteria - 19600; Metazoa - 61665; Fungi - 11208; Plants - 7696; Viruses - 409; Other Eukaryotes - 38949 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      20330680..20336866
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001339702.1 → NP_001326426.1  Armadillo/beta-catenin repeat family protein / kinesin motor family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A9CP38, F4JE41, Q9SV36
      UniProtKB/TrEMBL
      A0A178V659, A0A178V7N7, A0A5S9XKV4
      Conserved Domains (4) summary
      COG1196
      Location:472 → 757
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4372
      Location:647 → 869
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      cd00106
      Location:121 → 439
      KISc; Kinesin motor domain
      sd00043
      Location:804 → 829
      ARM; armadillo repeat [structural motif]

    2. NM_001339703.1 → NP_001326427.1  Armadillo/beta-catenin repeat family protein / kinesin motor family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V7N7, A0A1I9LP88

    3. NM_115344.4 → NP_191047.3  Armadillo/beta-catenin repeat family protein / kinesin motor family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191047.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V7N7
      Conserved Domains (7) summary
      cd00020
      Location:798 → 914
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      cd00106
      Location:121 → 439
      KISc; Kinesin motor domain
      pfam00225
      Location:115 → 441
      Kinesin; Kinesin motor domain
      pfam07106
      Location:671 → 747
      TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
      pfam17045
      Location:436 → 752
      CEP63; Centrosomal protein of 63 kDa
      sd00043
      Location:804 → 829
      ARM; armadillo repeat [structural motif]
      cl12013
      Location:493 → 660
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SV36.2

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