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    DEG2 DEGP protease 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819406, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DEG2
    Official Full Name
    DEGP protease 2
    Primary source
    TAIR:AT2G47940
    Locus tag
    AT2G47940
    See related
    Araport:AT2G47940
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    DEGP protease 2; DEGP2; degradation of periplasmic proteins 2; EMB3117; EMBRYO DEFECTIVE 3117
    Summary
    Encodes DegP2 protease (DEGP2); nuclear gene for chloroplast product.
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    Genomic context

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    See DEG2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    19
    Sequence:
    Chromosome: 2; NC_003071.7 (19617986..19622301, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Kinase interacting (KIP1-like) family protein Neighboring gene uncharacterized protein Neighboring gene arabinogalactan protein 26 Neighboring gene miscRNA Neighboring gene myelin transcription factor-like protein Neighboring gene trafficking protein particle complex subunit-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of Arabidopsis Deg2 protein reveals an internal PDZ ligand locking the hexameric resting state. Sun R, et al. J Biol Chem, 2012 Oct 26. PMID 22961982, Free PMC Article
    2. Photodamaged D1 protein is degraded in Arabidopsis mutants lacking the Deg2 protease. Huesgen PF, et al. FEBS Lett, 2006 Dec 22. PMID 17157840
    3. A chloroplast DegP2 protease performs the primary cleavage of the photodamaged D1 protein in plant photosystem II. Haussühl K, et al. EMBO J, 2001 Feb 15. PMID 11179216, Free PMC Article
    4. The thylakoid protease Deg2 is involved in stress-related degradation of the photosystem II light-harvesting protein Lhcb6 in Arabidopsis thaliana. Luciński R, et al. New Phytol, 2011 Oct. PMID 21668884
    5. A critical role for the Var2 FtsH homologue of Arabidopsis thaliana in the photosystem II repair cycle in vivo. Bailey S, et al. J Biol Chem, 2002 Jan 18. PMID 11717304

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Crystal structure of a conserved internal ligand of deg2 that mediates hexamer formation and locks the protease in the resting state.
      Title: Crystal structure of Arabidopsis Deg2 protein reveals an internal PDZ ligand locking the hexameric resting state.
    2. Deg2 is required for normal plant development, including the chloroplast life cycle, and has an important function in the degradation of Lhcb6 in response to short-duration stresses.
      Title: The thylakoid protease Deg2 is involved in stress-related degradation of the photosystem II light-harvesting protein Lhcb6 in Arabidopsis thaliana.
    3. rate of D1 protein degradation under light stress conditions in Arabidopsis mutants lacking the Deg2 protease is similar to those in wild-type plants. [Deg2]
      Title: Photodamaged D1 protein is degraded in Arabidopsis mutants lacking the Deg2 protease.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_001125072.1
    NM_130361.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chloroplast organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within photosystem II repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast stroma HDA PubMed 
    located_in chloroplast stromal thylakoid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast thylakoid membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    DEGP protease 2
    NP_001118544.1
    • DEGP protease 2 (DEGP2); FUNCTIONS IN: serine-type peptidase activity, serine-type endopeptidase activity; INVOLVED IN: photosystem II repair, proteolysis; LOCATED IN: chloroplast stromal thylakoid, chloroplast thylakoid membrane, chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Serine endopeptidase DegP2 (InterPro:IPR015724), Serine/cysteine peptidase, trypsin-like (InterPro:IPR009003), Peptidase S1C, HrtA/DegP2/Q/S (InterPro:IPR001940), Peptidase S1/S6, chymotrypsin/Hap (InterPro:IPR001254), PDZ/DHR/GLGF (InterPro:IPR001478); BEST Arabidopsis thaliana protein match is: DegP protease 9 (TAIR:AT5G40200.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_566115.1
    • DEGP protease 2 (DEGP2); FUNCTIONS IN: serine-type peptidase activity, serine-type endopeptidase activity; INVOLVED IN: photosystem II repair, proteolysis; LOCATED IN: chloroplast stromal thylakoid, chloroplast thylakoid membrane, chloroplast stroma, chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Serine/cysteine peptidase, trypsin-like (InterPro:IPR009003), Serine endopeptidase DegP2 (InterPro:IPR015724), Peptidase S1C, HrtA/DegP2/Q/S (InterPro:IPR001940), Peptidase S1/S6, chymotrypsin/Hap (InterPro:IPR001254), PDZ/DHR/GLGF (InterPro:IPR001478); BEST Arabidopsis thaliana protein match is: DegP protease 9 (TAIR:AT5G40200.1); Has 15046 Blast hits to 15035 proteins in 2533 species: Archae - 101; Bacteria - 10614; Metazoa - 317; Fungi - 14; Plants - 376; Viruses - 0; Other Eukaryotes - 3624 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      19617986..19622301 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130361.5 → NP_566115.1  DEGP protease 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566115.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O82261, Q9FPE9
      UniProtKB/TrEMBL
      A0A178VUR8, A0A5S9X8G7
      Conserved Domains (2) summary
      TIGR02037
      Location:135 → 458
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
      pfam17815
      Location:429 → 570
      PDZ_3; PDZ domain

    2. NM_001125072.1 → NP_001118544.1  DEGP protease 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001118544.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3H581
      Conserved Domains (3) summary
      cd00987
      Location:320 → 419
      PDZ_serine_protease; PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind ...
      pfam00089
      Location:123 → 307
      Trypsin; Trypsin
      pfam13365
      Location:143 → 281
      Trypsin_2; Trypsin-like peptidase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O82261.2

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