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    Esco1 establishment of sister chromatid cohesion N-acetyltransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 77805, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Esco1provided by MGI
    Official Full Name
    establishment of sister chromatid cohesion N-acetyltransferase 1provided by MGI
    Primary source
    MGI:MGI:1925055
    See related
    Ensembl:ENSMUSG00000024293 AllianceGenome:MGI:1925055
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A930014I12Rik
    Summary
    Predicted to enable identical protein binding activity; peptide-lysine-N-acetyltransferase activity; and zinc ion binding activity. Predicted to be involved in mitotic sister chromatid cohesion; protein acetylation; and regulation of DNA replication. Predicted to be located in chromatin. Predicted to be active in nucleus. Is expressed in cerebral cortex ventricular layer; gonad; reproductive system; and urinary system. Orthologous to human ESCO1 (establishment of sister chromatid cohesion N-acetyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 3.4), bladder adult (RPKM 2.6) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Esco1 in Genome Data Viewer
    Location:
    18 A1; 18 5.21 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (10566507..10610863, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (10566507..10610863, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43791 Neighboring gene STARR-seq mESC enhancer starr_43793 Neighboring gene RAE1 RNA export 1 homolog pseudogene Neighboring gene growth regulation by estrogen in breast cancer-like Neighboring gene nuclear transport factor 2, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_43798 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:10532920-10533103 Neighboring gene small nuclear ribonucleoprotein D1 Neighboring gene abhydrolase domain containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The cohesion establishment factor Esco1 acetylates α-tubulin to ensure proper spindle assembly in oocyte meiosis. Lu Y, et al. Nucleic Acids Res, 2018 Mar 16. PMID 29361031, Free PMC Article
    2. Alternative catalytic residues in the active site of Esco acetyltransferases. Ajam T, et al. Sci Rep, 2020 Jun 17. PMID 32555289, Free PMC Article
    3. Molecular Profiling Reveals Involvement of ESCO2 in Intermediate Progenitor Cell Maintenance in the Developing Mouse Cortex. Ulmke PA, et al. Stem Cell Reports, 2021 Apr 13. PMID 33798452, Free PMC Article
    4. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Alternative catalytic residues in the active site of Esco acetyltransferases.
      Title: Alternative catalytic residues in the active site of Esco acetyltransferases.
    2. Esco1 is required for alpha-tubulin acetylation and microtubule stability, which thereby ensures normal spindle assembly and proper chromosome alignment to orchestrate the mouse oocyte meiotic progression.
      Title: The cohesion establishment factor Esco1 acetylates α-tubulin to ensure proper spindle assembly in oocyte meiosis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables N-acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptide-lysine-N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide-lysine-N-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptide-lysine-N-acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitotic sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-lysine acetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-lysine acetylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in post-translational protein acetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in post-translational protein acetylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA replication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    N-acetyltransferase ESCO1
    Names
    ECO1 homolog 1
    establishment of cohesion 1 homolog 1
    establisment of cohesion 1 homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081222.1 → NP_001074691.1  N-acetyltransferase ESCO1

      See identical proteins and their annotated locations for NP_001074691.1

      Status: PROVISIONAL

      Source sequence(s)
      AC102441, AC105947
      Consensus CDS
      CCDS37737.1
      UniProtKB/Swiss-Prot
      B9EKQ9, Q69Z69, Q8BQI2, Q8BR47, Q922F5
      UniProtKB/TrEMBL
      Q3ULS5
      Related
      ENSMUSP00000025142.6, ENSMUST00000025142.13
      Conserved Domains (2) summary
      pfam13878
      Location:607 → 646
      zf-C2H2_3; zinc-finger of acetyl-transferase ESCO
      pfam13880
      Location:766 → 828
      Acetyltransf_13; ESCO1/2 acetyl-transferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      10566507..10610863 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526353.4 → XP_006526416.1  N-acetyltransferase ESCO1 isoform X1

      See identical proteins and their annotated locations for XP_006526416.1

      UniProtKB/TrEMBL
      Q3UKT9
      Related
      ENSMUSP00000095274.4, ENSMUST00000097670.10
      Conserved Domains (2) summary
      pfam13878
      Location:108 → 147
      zf-C2H2_3; zinc-finger of acetyl-transferase ESCO
      pfam13880
      Location:267 → 335
      Acetyltransf_13; ESCO1/2 acetyl-transferase

    2. XM_036161309.1 → XP_036017202.1  N-acetyltransferase ESCO1 isoform X2

      Related
      ENSMUSP00000111530.2, ENSMUST00000115864.8
      Conserved Domains (2) summary
      pfam13878
      Location:83 → 122
      zf-C2H2_3; zinc-finger of acetyl-transferase ESCO
      pfam13880
      Location:242 → 310
      Acetyltransf_13; ESCO1/2 acetyl-transferase

    RNA

    1. XR_003952544.1 RNA Sequence

      Related
      ENSMUST00000127099.9

    2. XR_001782403.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_144542.1: Suppressed sequence

      Description
      NM_144542.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q69Z69.2 GenPept UniProtKB/Swiss-Prot:Q69Z69

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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