Slc18b1 solute carrier family 18, subfamily B, member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc18b1provided by MGI
Official Full Name: solute carrier family 18, subfamily B, member 1provided by MGI
Primary source: MGI:MGI:1923556
See related: Ensembl:ENSMUSG00000037455 AllianceGenome:MGI:1923556
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: VPAT; 1110021L09Rik
Summary: Predicted to enable monoamine:proton antiporter activity and polyamine:proton antiporter activity. Involved in spermidine transport and spermine transport. Located in secretory granule membrane. Is expressed in dorsal root ganglion and spinal cord. Orthologous to human SLC18B1 (solute carrier family 18 member B1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in subcutaneous fat pad adult (RPKM 9.6), large intestine adult (RPKM 9.6) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 A4; 10 11.12 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (23672876..23703867)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (23796859..23827969)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that removal of Slc18b1 leads to reduction of polyamine contents in neurons, resulting in reduced GABA signaling due to long-term reduction in glutamatergic signaling.
Title: The polyamine transporter Slc18b1(VPAT) is important for both short and long time memory and for regulation of polyamine content in the brain.
VPAT is expressed and is responsible for vesicular storage of spermine and spermidine in novel secretory granules that differ from histamine- and serotonin-containing granules and is involved in vesicular release of these polyamines from mast cells
Title: Vesicular Polyamine Transporter Mediates Vesicular Storage and Release of Polyamine from Mast Cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (1) 1 citation

General gene information

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Markers

px-31f3 (e-PCR)
- UniSTS:257585

D13Sfk9 (e-PCR), detects polymorphism
- UniSTS:141961

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables monoamine:proton antiporter activity	ISO Inferred from Sequence Orthology more info
enables monoamine:proton antiporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables polyamine:proton antiporter activity	ISO Inferred from Sequence Orthology more info
enables polyamine:proton antiporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in polyamine transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in serotonin uptake	ISO Inferred from Sequence Orthology more info
involved_in serotonin uptake	ISS Inferred from Sequence or Structural Similarity more info
involved_in spermidine transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermidine transport	ISO Inferred from Sequence Orthology more info
involved_in spermidine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in spermine transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermine transport	ISO Inferred from Sequence Orthology more info
involved_in spermine transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in secretory granule membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: MFS-type transporter SLC18B1

Names: MFS-type transporter C6orf192 homolog; solute carrier family 18 member B1; vesicular polyamine transporter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001358812.2 → NP_001345741.1 MFS-type transporter SLC18B1 isoform 2

Status: VALIDATED

Source sequence(s)

AC153973, AC160147

UniProtKB/Swiss-Prot

D3Z5L6

Conserved Domains (1) summary

pfam07690
Location:1 → 322

MFS_1; Major Facilitator Superfamily
NM_001358813.2 → NP_001345742.1 MFS-type transporter SLC18B1 isoform 3

Status: VALIDATED

Source sequence(s)

AC153973, AC160147

Conserved Domains (1) summary

cl28910
Location:3 → 190

MFS; Major Facilitator Superfamily
NM_001408212.1 → NP_001395141.1 MFS-type transporter SLC18B1 isoform 4

Status: VALIDATED

Source sequence(s)

AC153973, AC160147
NM_001408213.1 → NP_001395142.1 MFS-type transporter SLC18B1 isoform 5

Status: VALIDATED

Source sequence(s)

AC153973, AC160147
NM_001408214.1 → NP_001395143.1 MFS-type transporter SLC18B1 isoform 3

Status: VALIDATED

Source sequence(s)

AC153973, AC160147
NM_001408215.1 → NP_001395144.1 MFS-type transporter SLC18B1 isoform 3

Status: VALIDATED

Source sequence(s)

AC153973, AC160147
NM_183116.3 → NP_898939.2 MFS-type transporter SLC18B1 isoform 1

Status: VALIDATED

Source sequence(s)

AC153973, AC160147

Consensus CDS

CCDS48521.1

UniProtKB/Swiss-Prot

D3Z5L6

UniProtKB/TrEMBL

E9PU92

Related

ENSMUSP00000112634.2, ENSMUST00000119597.8

Conserved Domains (2) summary

cd06174
Location:37 → 426

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam07690
Location:48 → 392

MFS_1; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

23672876..23703867

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030245356.1 → XP_030101216.1 MFS-type transporter SLC18B1 isoform X2

Conserved Domains (1) summary

cl28910
Location:3 → 190

MFS; Major Facilitator Superfamily
XM_030245355.1 → XP_030101215.1 MFS-type transporter SLC18B1 isoform X1

Conserved Domains (1) summary

cl28910
Location:1 → 295

MFS; Major Facilitator Superfamily