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    Lyrm1 LYR motif containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 73919, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Lyrm1provided by MGI
    Official Full Name
    LYR motif containing 1provided by MGI
    Primary source
    MGI:MGI:1921169
    See related
    Ensembl:ENSMUSG00000030922 AllianceGenome:MGI:1921169
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110065L10Rik; 2310004B22Rik; 4930404J24Rik
    Summary
    Located in mitochondrion. Orthologous to human LYRM1 (LYR motif containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis adult (RPKM 3.1), CNS E18 (RPKM 0.8) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lyrm1 in Genome Data Viewer
    Location:
    7 F2; 7 64.31 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (119495038..119515979)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (119895713..119916756)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene acyl-CoA synthetase medium-chain family member 3 Neighboring gene exoribonuclease 2 Neighboring gene RNA exonuclease 5 Neighboring gene STARR-seq mESC enhancer starr_20039 Neighboring gene defective in cullin neddylation 1 domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E3747 Neighboring gene STARR-seq mESC enhancer starr_20040 Neighboring gene STARR-seq mESC enhancer starr_20041 Neighboring gene dynein, axonemal, heavy chain 3 Neighboring gene predicted gene, 53369 Neighboring gene predicted gene, 25217

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Knockdown of LYRM1 rescues insulin resistance and mitochondrial dysfunction induced by FCCP in 3T3-L1 adipocytes. Zhang M, et al. Cell Biochem Biophys, 2014 Sep. PMID 24771405
    2. Effects of Lyrm1 knockdown on mitochondrial function in 3 T3-L1 murine adipocytes. Zhu GZ, et al. J Bioenerg Biomembr, 2012 Feb. PMID 22249831
    3. Regulation of LYRM1 gene expression by free fatty acids, adipokines, and rosiglitazone in 3T3-L1 adipocytes. Zhang M, et al. Exp Diabetes Res, 2012. PMID 22110480, Free PMC Article
    4. Effect of LYRM1 knockdown on proliferation, apoptosis, differentiation and mitochondrial function in the P19 cell model of cardiac differentiation in vitro. Chen YM, et al. J Bioenerg Biomembr, 2016 Feb. PMID 26759027, Free PMC Article
    5. α-Lipoic acid ameliorates impaired glucose uptake in LYRM1 overexpressing 3T3-L1 adipocytes through the IRS-1/Akt signaling pathway. Qin ZY, et al. J Bioenerg Biomembr, 2012 Oct. PMID 22820890

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. knockdown of LYRM1 induced mitochondrial impairment in P19 cells during differentiation, which was reflected by decreased ATP synthesis, lower MMP and increased ROS levels.
      Title: Effect of LYRM1 knockdown on proliferation, apoptosis, differentiation and mitochondrial function in the P19 cell model of cardiac differentiation in vitro.
    2. FCCP-induced mitochondrial dysfunction and insulin resistance are ameliorated by knockdown of LYRM1
      Title: Knockdown of LYRM1 rescues insulin resistance and mitochondrial dysfunction induced by FCCP in 3T3-L1 adipocytes.
    3. alpha-LA protects 3T3-L1 adipocytes from LYRM1-induced insulin resistance partially via its capacity to restore mitochondrial function and/or increase phosphorylation of IRS-1 and Akt.
      Title: α-Lipoic acid ameliorates impaired glucose uptake in LYRM1 overexpressing 3T3-L1 adipocytes through the IRS-1/Akt signaling pathway.
    4. Knockdown of the Lyrm1 gene in adipocytes resulted in dramatically increased cellular ATP production, mitochondrial membrane potentials and levels Ucp2 mRNA, while ROS levels were significantly decreased.
      Title: Effects of Lyrm1 knockdown on mitochondrial function in 3 T3-L1 murine adipocytes.
    5. results suggest that the expression of LYRM1 mRNA is affected by a variety of factors that are related to insulin sensitivity; LYRM1 may be an important mediator in the development of obesity-related insulin resistance
      Title: Regulation of LYRM1 gene expression by free fatty acids, adipokines, and rosiglitazone in 3T3-L1 adipocytes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    LYR motif-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285959.1 → NP_001272888.1  LYR motif-containing protein 1

      See identical proteins and their annotated locations for NP_001272888.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 all encode the same protein.
      Source sequence(s)
      AC131702, BU757765, BY464772, DV043140
      Consensus CDS
      CCDS21790.1
      UniProtKB/Swiss-Prot
      Q3TZE0, Q9CQB7
      Related
      ENSMUSP00000102128.2, ENSMUST00000106518.9
      Conserved Domains (1) summary
      cd20261
      Location:8 → 83
      Complex1_LYR_LYRM1; LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and similar proteins

    2. NM_001285960.1 → NP_001272889.1  LYR motif-containing protein 1

      See identical proteins and their annotated locations for NP_001272889.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 all encode the same protein.
      Source sequence(s)
      AC131702, BU757765, BY464772, DV043140
      Consensus CDS
      CCDS21790.1
      UniProtKB/Swiss-Prot
      Q3TZE0, Q9CQB7
      Related
      ENSMUSP00000146699.2, ENSMUST00000208202.2
      Conserved Domains (1) summary
      cd20261
      Location:8 → 83
      Complex1_LYR_LYRM1; LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and similar proteins

    3. NM_001285961.2 → NP_001272890.1  LYR motif-containing protein 1

      See identical proteins and their annotated locations for NP_001272890.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 all encode the same protein.
      Source sequence(s)
      AC131702, AK009135, AK015083, BY752674
      Consensus CDS
      CCDS21790.1
      UniProtKB/Swiss-Prot
      Q3TZE0, Q9CQB7
      Related
      ENSMUSP00000051616.4, ENSMUST00000054440.11
      Conserved Domains (1) summary
      cd20261
      Location:8 → 83
      Complex1_LYR_LYRM1; LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and similar proteins

    4. NM_029610.3 → NP_083886.1  LYR motif-containing protein 1

      See identical proteins and their annotated locations for NP_083886.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, and 4 all encode the same protein.
      Source sequence(s)
      AK009135, BY464772
      Consensus CDS
      CCDS21790.1
      UniProtKB/Swiss-Prot
      Q3TZE0, Q9CQB7
      Related
      ENSMUSP00000102127.2, ENSMUST00000106517.9
      Conserved Domains (1) summary
      cd20261
      Location:8 → 83
      Complex1_LYR_LYRM1; LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and similar proteins

    RNA

    1. NR_126475.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) contains an alternate first exon and lacks an internal exon compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AC131702

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      119495038..119515979
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508239.5 → XP_006508302.1  LYR motif-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006508302.1

      UniProtKB/Swiss-Prot
      Q3TZE0, Q9CQB7
      Conserved Domains (1) summary
      cd20261
      Location:8 → 83
      Complex1_LYR_LYRM1; LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and similar proteins

    2. XM_006508240.4 → XP_006508303.1  LYR motif-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006508303.1

      UniProtKB/Swiss-Prot
      Q3TZE0, Q9CQB7
      Conserved Domains (1) summary
      cd20261
      Location:8 → 83
      Complex1_LYR_LYRM1; LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and similar proteins

    3. XM_006508237.4 → XP_006508300.1  LYR motif-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006508300.1

      UniProtKB/Swiss-Prot
      Q3TZE0, Q9CQB7
      Conserved Domains (1) summary
      cd20261
      Location:8 → 83
      Complex1_LYR_LYRM1; LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and similar proteins

    4. XM_006508244.4 → XP_006508307.1  LYR motif-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006508307.1

      UniProtKB/Swiss-Prot
      Q3TZE0, Q9CQB7
      Conserved Domains (1) summary
      cd20261
      Location:8 → 83
      Complex1_LYR_LYRM1; LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and similar proteins

    5. XM_006508243.4 → XP_006508306.1  LYR motif-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006508306.1

      UniProtKB/Swiss-Prot
      Q3TZE0, Q9CQB7
      Conserved Domains (1) summary
      cd20261
      Location:8 → 83
      Complex1_LYR_LYRM1; LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and similar proteins

    6. XM_006508238.4 → XP_006508301.1  LYR motif-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006508301.1

      UniProtKB/Swiss-Prot
      Q3TZE0, Q9CQB7
      Conserved Domains (1) summary
      cd20261
      Location:8 → 83
      Complex1_LYR_LYRM1; LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and similar proteins

    7. XM_036153480.1 → XP_036009373.1  LYR motif-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q3TZE0, Q9CQB7
      Conserved Domains (1) summary
      cd20261
      Location:8 → 83
      Complex1_LYR_LYRM1; LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and similar proteins

    8. XM_006508241.4 → XP_006508304.1  LYR motif-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006508304.1

      UniProtKB/Swiss-Prot
      Q3TZE0, Q9CQB7
      Conserved Domains (1) summary
      cd20261
      Location:8 → 83
      Complex1_LYR_LYRM1; LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and similar proteins

    9. XM_006508234.5 → XP_006508297.1  LYR motif-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006508297.1

      UniProtKB/Swiss-Prot
      Q3TZE0, Q9CQB7
      Conserved Domains (1) summary
      cd20261
      Location:8 → 83
      Complex1_LYR_LYRM1; LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and similar proteins

    10. XM_006508235.5 → XP_006508298.1  LYR motif-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006508298.1

      UniProtKB/Swiss-Prot
      Q3TZE0, Q9CQB7
      Conserved Domains (1) summary
      cd20261
      Location:8 → 83
      Complex1_LYR_LYRM1; LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and similar proteins

    11. XM_006508236.5 → XP_006508299.1  LYR motif-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006508299.1

      UniProtKB/Swiss-Prot
      Q3TZE0, Q9CQB7
      Conserved Domains (1) summary
      cd20261
      Location:8 → 83
      Complex1_LYR_LYRM1; LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and similar proteins

    12. XM_036153479.1 → XP_036009372.1  LYR motif-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q3TZE0, Q9CQB7
      Conserved Domains (1) summary
      cd20261
      Location:8 → 83
      Complex1_LYR_LYRM1; LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and similar proteins

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_104377.1: Suppressed sequence

      Description
      NR_104377.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQB7.1 GenPept UniProtKB/Swiss-Prot:Q9CQB7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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