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    Zfp974 zinc finger protein 974 [ Mus musculus (house mouse) ]

    Gene ID: 73430, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Zfp974provided by MGI
    Official Full Name
    zinc finger protein 974provided by MGI
    Primary source
    MGI:MGI:1920680
    See related
    Ensembl:ENSMUSG00000070709 AllianceGenome:MGI:1920680
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700049G17Rik
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in bladder; central nervous system; testis; ureter; and urethra of male. Orthologous to human ZNF780A (zinc finger protein 780A) and ZNF780B (zinc finger protein 780B). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in bladder adult (RPKM 1.9), CNS E18 (RPKM 1.6) and 20 other tissues See more
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    Genomic context

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    See Zfp974 in Genome Data Viewer
    Location:
    7 A3; 7 15.97 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (27604839..27629124, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (27905414..27929699, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18392 Neighboring gene zinc finger protein 59 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:28645358-28645700 Neighboring gene zinc finger protein 607A Neighboring gene STARR-seq mESC enhancer starr_18395 Neighboring gene protein kinase C, zeta 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:28718534-28718717 Neighboring gene STARR-positive B cell enhancer ABC_E4911 Neighboring gene predicted gene, 26891 Neighboring gene predicted gene, 53355 Neighboring gene Josephin domain containing 1, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    2. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 974

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001374027.1 → NP_001360956.1  zinc finger protein 974 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC139063
      UniProtKB/TrEMBL
      B9EJ82
      Conserved Domains (3) summary
      smart00349
      Location:14 → 75
      KRAB; krueppel associated box
      COG5048
      Location:199 → 574
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:417 → 437
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_028538.3 → NP_082814.1  zinc finger protein 974 isoform 2

      See identical proteins and their annotated locations for NP_082814.1

      Status: VALIDATED

      Source sequence(s)
      AC139063
      Consensus CDS
      CCDS21032.1
      UniProtKB/TrEMBL
      Q3UVF6
      Related
      ENSMUSP00000096238.3, ENSMUST00000098639.9
      Conserved Domains (2) summary
      COG5048
      Location:125 → 500
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:343 → 363
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      27604839..27629124 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153468.1 → XP_036009361.1  zinc finger protein 974 isoform X2

      UniProtKB/TrEMBL
      Q3UVF6
      Conserved Domains (2) summary
      COG5048
      Location:125 → 500
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:343 → 363
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_030243021.1 → XP_030098881.1  zinc finger protein 974 isoform X1

      UniProtKB/TrEMBL
      B9EJ82
      Conserved Domains (3) summary
      smart00349
      Location:14 → 75
      KRAB; krueppel associated box
      COG5048
      Location:199 → 574
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:417 → 437
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_030243020.2 → XP_030098880.1  zinc finger protein 974 isoform X1

      UniProtKB/TrEMBL
      B9EJ82
      Conserved Domains (3) summary
      smart00349
      Location:14 → 75
      KRAB; krueppel associated box
      COG5048
      Location:199 → 574
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:417 → 437
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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