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    Ear14 eosinophil-associated, ribonuclease A family, member 14 [ Mus musculus (house mouse) ]

    Gene ID: 503847, updated on 18-Sep-2024

    Summary

    Official Symbol
    Ear14provided by MGI
    Official Full Name
    eosinophil-associated, ribonuclease A family, member 14provided by MGI
    Primary source
    MGI:MGI:3528616
    See related
    Ensembl:ENSMUSG00000050766 AllianceGenome:MGI:3528616
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable ribonuclease activity. Predicted to be involved in chemotaxis and innate immune response in mucosa. Predicted to be active in extracellular space. Orthologous to human RNASE2 (ribonuclease A family member 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

    See Ear14 in Genome Data Viewer
    Location:
    14 C1; 14 26.42 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (51441152..51441613)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (51203695..51204156)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene eosinophil-associated, ribonuclease A family, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_36667 Neighboring gene STARR-seq mESC enhancer starr_36668 Neighboring gene angiogenin, ribonuclease A family, member 2 Neighboring gene STARR-seq mESC enhancer starr_36669 Neighboring gene STARR-seq mESC enhancer starr_36670 Neighboring gene ribonuclease, RNase A family, 2A (liver, eosinophil-derived neurotoxin) Neighboring gene predicted gene 7106

    Genomic regions, transcripts, and products

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA nuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA nuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipopolysaccharide binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in defense response to Gram-positive bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in innate immune response in mucosa IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    eosinophil-associated, ribonuclease A family, member 14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017389.2NP_059085.2  eosinophil-associated, ribonuclease A family, member 14 precursor

      See identical proteins and their annotated locations for NP_059085.2

      Status: PROVISIONAL

      Source sequence(s)
      AY665809
      Consensus CDS
      CCDS88652.1
      UniProtKB/TrEMBL
      Q5GAN2, W0UTF4
      Related
      ENSMUSP00000056293.2, ENSMUST00000049559.2
      Conserved Domains (1) summary
      pfam00074
      Location:29150
      RnaseA; Pancreatic ribonuclease

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      51441152..51441613
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)