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    pdp1.L pyruvate dehydrogenase phosphatase catalytic subunit 1 L homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 447514, updated on 4-Nov-2024

    Summary

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    Official Symbol
    pdp1.L
    Official Full Name
    pyruvate dehydrogenase phosphatase catalytic subunit 1 L homeolog
    Primary source
    Xenbase:XB-GENE-6253767
    See related
    EnsemblRapid:ENSXLAG00005032374 AllianceGenome:Xenbase:XB-GENE-6253767
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    pdp1; ppm2c
    Summary
    Predicted to enable [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity and metal ion binding activity. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in obesity and pyruvate decarboxylase deficiency. Orthologous to human PDP1 (pyruvate dehydrogenase phosphatase catalytic subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
    Annotation information
    Annotation category: partial on reference assembly
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    Genomic context

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    See pdp1.L in Genome Data Viewer
    Location:
    chromosome: 6L
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 6L NC_054381.1 (137696414..137705875, complement)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 6L NC_030734.1 (128527784..128568939, complement)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) Unplaced Scaffold NW_016758690.1 (1..315, complement)

    Chromosome 6L - NC_054381.1Genomic Context describing neighboring genes Neighboring gene RNA-binding protein 12B Neighboring gene RNA binding motif protein 12B-like Neighboring gene pyruvate dehydrogenase [acetyl-transferring]-phosphatase 1, mitochondrial Neighboring gene RNA-binding protein 12B-like Neighboring gene traf2 and NCK-interacting protein kinase-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC82628

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cation binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pyruvate dehydrogenase phosphatase catalytic subunit 1 L homeolog
    Names
    pyruvate dehyrogenase phosphatase catalytic subunit 1 L homeolog
    NP_001087690.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001094221.1 → NP_001087690.1  pyruvate dehydrogenase phosphatase catalytic subunit 1 L homeolog

      See identical proteins and their annotated locations for NP_001087690.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081088
      UniProtKB/TrEMBL
      Q66J23
      Related
      ENSXLAP00005097005.1, ENSXLAT00005098787.1
      Conserved Domains (1) summary
      cd00143
      Location:102 → 515
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054381.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      137696414..137705875 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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