Tmprss9 transmembrane protease, serine 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmprss9provided by MGI
Official Full Name: transmembrane protease, serine 9provided by MGI
Primary source: MGI:MGI:3612246
See related: Ensembl:ENSMUSG00000059406 AllianceGenome:MGI:3612246
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Serase-1B
Summary: Enables serine-type peptidase activity. Acts upstream of or within plasminogen activation. Predicted to be located in plasma membrane. Used to study autism spectrum disorder. Orthologous to human TMPRSS9 (transmembrane serine protease 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in stomach adult (RPKM 19.4), testis adult (RPKM 1.4) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (80706951..80735329)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (80871117..80899495)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Combination of whole exome sequencing and animal modeling identifies TMPRSS9 as a candidate gene for autism spectrum disorder.
Title: Combination of whole exome sequencing and animal modeling identifies TMPRSS9 as a candidate gene for autism spectrum disorder.
These data suggest that the expression of mpolyserase-1 and its transcript variants is positively regulated by the E-box in its 5'-UTR.
Title: Identification and analysis of the promoter region of the type II transmembrane serine protease polyserase-1 and its transcript variants.
The isolation and characterization of serase-1B, a splice variant of polyserase-1, is reported.
Title: Serase-1B, a new splice variant of polyserase-1/TMPRSS9, activates urokinase-type plasminogen activator and the proteolytic activation is negatively regulated by glycosaminoglycans.
Figure 6 in the publisher's supporting information shows an alignment of the identified (human) and predicted (mouse and rat) amino acid sequences.
Title: Polyserase-I, a human polyprotease with the ability to generate independent serine protease domains from a single translation product.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

General gene information

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Markers

D10Ertd378e (e-PCR), detects polymorphism
- UniSTS:167012

NoName (e-PCR)
- UniSTS:236400

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables serine-type peptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within plasminogen activation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within proteolysis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transmembrane protease serine 9

Names: polyserase-1; polyserase-I; polyserine protease-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081688.2 → NP_001075157.2 transmembrane protease serine 9

Status: VALIDATED

Source sequence(s)

AC152413, AC166937

Consensus CDS

CCDS48641.1

UniProtKB/TrEMBL

B2RY54, D3YTR8

Related

ENSMUSP00000100970.3, ENSMUST00000105333.3

Conserved Domains (4) summary

smart00020
Location:238 → 467

Tryp_SPc; Trypsin-like serine protease

cd00112
Location:190 → 225

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cd00190
Location:239 → 467

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam01390
Location:68 → 148

SEA; SEA domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

80706951..80735329

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006513843.2 → XP_006513906.2 transmembrane protease serine 9 isoform X2

UniProtKB/TrEMBL

B2RY54

Conserved Domains (4) summary

smart00020
Location:748 → 976

Tryp_SPc; Trypsin-like serine protease

cd00112
Location:407 → 442

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cd00190
Location:1077 → 1328

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam01390
Location:285 → 365

SEA; SEA domain
XM_006513842.2 → XP_006513905.2 transmembrane protease serine 9 isoform X1

UniProtKB/TrEMBL

B2RY54

Conserved Domains (4) summary

smart00020
Location:455 → 684

Tryp_SPc; Trypsin-like serine protease

cd00112
Location:407 → 442

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cd00190
Location:1085 → 1336

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam01390
Location:285 → 365

SEA; SEA domain
XM_006513845.2 → XP_006513908.2 transmembrane protease serine 9 isoform X4

UniProtKB/TrEMBL

B2RY54

Conserved Domains (4) summary

smart00020
Location:455 → 684

Tryp_SPc; Trypsin-like serine protease

cd00112
Location:407 → 442

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cd00190
Location:1085 → 1310

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam01390
Location:285 → 365

SEA; SEA domain
XM_006513844.2 → XP_006513907.2 transmembrane protease serine 9 isoform X3

UniProtKB/TrEMBL

B2RY54

Conserved Domains (3) summary

smart00020
Location:441 → 670

Tryp_SPc; Trypsin-like serine protease

cd00112
Location:393 → 428

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam01390
Location:285 → 365

SEA; SEA domain