Pglyrp4 peptidoglycan recognition protein 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pglyrp4provided by MGI
Official Full Name: peptidoglycan recognition protein 4provided by MGI
Primary source: MGI:MGI:2686324
See related: Ensembl:ENSMUSG00000042250 AllianceGenome:MGI:2686324
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm413; Gm1478
Summary: Predicted to enable peptidoglycan binding activity; peptidoglycan immune receptor activity; and protein heterodimerization activity. Acts upstream of or within biological process involved in interaction with host; negative regulation of natural killer cell differentiation involved in immune response; and negative regulation of type II interferon production. Predicted to be located in extracellular region. Predicted to be part of protein-containing complex. Is expressed in several structures, including alimentary system; genitourinary system; immune system; liver; and musculature. Orthologous to human PGLYRP4 (peptidoglycan recognition protein 4). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 3 F1; 3 39.96 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (90634008..90648824)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (90726906..90741517)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pglyrp-2 expression was induced after infection in WT mice. Pglyrp-3 expression was low before and after infection in WT mice, while Pglyrp-4 expression was slightly elevated after infection in WT, Pglyrp-2 and -3 null mice
Title: Functions of Peptidoglycan Recognition Proteins (Pglyrps) at the Ocular Surface: Bacterial Keratitis in Gene-Targeted Mice Deficient in Pglyrp-2, -3 and -4.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

General gene information

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Markers

RH131758 (e-PCR)
- UniSTS:215041

px-31f3 (e-PCR)
- UniSTS:257585

D1S3697 (e-PCR)
- UniSTS:474275

NoName (e-PCR)
- UniSTS:491974

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables N-acetylmuramoyl-L-alanine amidase activity	IEA Inferred from Electronic Annotation more info
enables peptidoglycan binding	ISO Inferred from Sequence Orthology more info
enables peptidoglycan binding	ISS Inferred from Sequence or Structural Similarity more info
enables peptidoglycan immune receptor activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within biological process involved in interaction with host	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to bacterium	IEA Inferred from Electronic Annotation more info
involved_in detection of bacterium	ISO Inferred from Sequence Orthology more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in killing of cells of another organism	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of natural killer cell differentiation involved in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of type II interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidoglycan catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: peptidoglycan recognition protein 4

Names: PGLYRPIbeta; PGRP-I-beta; peptidoglycan recognition protein I-beta; peptidoglycan recognition protein intermediate beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001165968.2 → NP_001159440.1 peptidoglycan recognition protein 4 isoform 1 precursor

See identical proteins and their annotated locations for NP_001159440.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC122425

Consensus CDS

CCDS50972.1

UniProtKB/TrEMBL

B7ZMZ4

Related

ENSMUSP00000128113.2, ENSMUST00000169698.8

Conserved Domains (1) summary

smart00701
Location:213 → 353

PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme
NM_207263.3 → NP_997146.2 peptidoglycan recognition protein 4 isoform 2 precursor

See identical proteins and their annotated locations for NP_997146.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1.

Source sequence(s)

AC122425

Consensus CDS

CCDS17544.1

UniProtKB/Swiss-Prot

Q0VB07, Q6R1Z1

Related

ENSMUSP00000040755.6, ENSMUST00000047745.6

Conserved Domains (1) summary

smart00701
Location:212 → 352

PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

90634008..90648824

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017319632.1 → XP_017175121.1 peptidoglycan recognition protein 4 isoform X1

Conserved Domains (1) summary

smart00701
Location:198 → 338

PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme