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    elav embryonic lethal abnormal vision [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31000, updated on 18-Sep-2024

    Summary

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    Official Symbol
    elavprovided by FlyBase
    Official Full Name
    embryonic lethal abnormal visionprovided by FlyBase
    Primary source
    FLYBASE:FBgn0260400
    Locus tag
    Dmel_CG4262
    See related
    AllianceGenome:FB:FBgn0260400
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    44C11; 9F8A9; CG4262; dHuR; Dmel\CG4262; EC7; EG:65F1.2; Elav; ElaV; ELav; ELAV; elav-1; elav-2; elav-3; Elav-9F8A9; END1-2; fliJ; l(1)1Be; l(1)EC7; l(1)G0031; l(1)G0319; weg
    Summary
    Enables poly(U) RNA binding activity. Involved in central nervous system development and negative regulation of mRNA 3'-end processing. Located in Cajal body. Is expressed in several structures, including eye-antennal disc; nervous system; photoreceptor; procephalic segment; and terminalia. Orthologous to human ELAVL3 (ELAV like RNA binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See elav in Genome Data Viewer
    Location:
    1B7-1B8; 1-0 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (509235..523226, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (403268..417259, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44891 Neighboring gene antisense RNA:CR44892 Neighboring gene silver Neighboring gene elav noncoding regulatory RNA Neighboring gene arginase Neighboring gene uncharacterized protein Neighboring gene beta amyloid protein precursor-like Neighboring gene mir-4960 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The biological characters of Bmelav-like genes in the development of Bombyx mori. Sun X, et al. Insect Mol Biol, 2021 Feb. PMID 32940384
    2. Cinnamaldehyde Improves Lifespan and Healthspan in Drosophila melanogaster Models for Alzheimer's Disease. Pham HM, et al. Biomed Res Int, 2018. PMID 30228985, Free PMC Article
    3. Sodium valproate alleviates neurodegeneration in SCA3/MJD via suppressing apoptosis and rescuing the hypoacetylation levels of histone H3 and H4. Yi J, et al. PLoS One, 2013. PMID 23382971, Free PMC Article
    4. Drosophila melanogaster: a new model to study cisplatin-induced neurotoxicity. Podratz JL, et al. Neurobiol Dis, 2011 Aug. PMID 21514385, Free PMC Article
    5. Design and utility of temperature-sensitive Gal4 mutants for conditional gene expression in Drosophila. Mondal K, et al. Fly (Austin), 2007 Sep-Oct. PMID 18836309

    See all (1281) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Repression of the Hox gene abd-A by ELAV-mediated Transcriptional Interference.
      Title: Repression of the Hox gene abd-A by ELAV-mediated Transcriptional Interference.
    2. The biological characters of Bmelav-like genes in the development of Bombyx mori.
      Title: The biological characters of Bmelav-like genes in the development of Bombyx mori.
    3. ELAV/Hu RNA binding proteins determine multiple programs of neural alternative splicing.
      Title: ELAV/Hu RNA binding proteins determine multiple programs of neural alternative splicing.
    4. ELAV and FNE Determine Neuronal Transcript Signatures through EXon-Activated Rescue.
      Title: ELAV and FNE Determine Neuronal Transcript Signatures through EXon-Activated Rescue.
    5. The Dscam1 long 3' UTR was found to be required for correct Elav-mediated skipping of exon 19. Elav thus co-regulates APA and alternative splicing to generate specific Dscam1 transcripts that are essential for neural development.
      Title: Elav-Mediated Exon Skipping and Alternative Polyadenylation of the Dscam1 Gene Are Required for Axon Outgrowth.
    6. Ubiquitous Elav has regulatory capacity, since derepressed Elav can stabilize an Elav-responsive sensor. Repression of Elav in non-neural territories is crucial as misexpression here has profoundly adverse consequences.
      Title: Neural specificity of the RNA-binding protein Elav is achieved by post-transcriptional repression in non-neural tissues.
    7. Paused Pol II promotes recruitment of ELAV to extended genes in Drosophila.
      Title: ELAV links paused Pol II to alternative polyadenylation in the Drosophila nervous system.
    8. The modulation of Hox RNA processing by ELAV serves to adapt the morphogenesis of the CNS to axial level by regulating Hox expression and consequently activating local programmes of neural differentiation.
      Title: The RNA-binding protein ELAV regulates Hox RNA processing, expression and function within the Drosophila nervous system.
    9. Reducing Elav levels significantly suppressed the worniu mutant phenotype.
      Title: The Snail family member Worniu is continuously required in neuroblasts to prevent Elav-induced premature differentiation.
    10. RNA immunoprecipitation assays suggest that ELAV directly binds the proximal polyadenylation signals of many target mRNAs
      Title: ELAV mediates 3' UTR extension in the Drosophila nervous system.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables mRNA binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables mRNA regulatory element binding translation repressor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables poly(U) RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in central nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in germ cell development NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of mRNA 3'-end processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of oskar mRNA translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in nervous system development NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Cajal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    embryonic lethal abnormal vision
    Names
    CG4262-PA
    CG4262-PB
    CG4262-PC
    CG4262-PD
    elav
    elav-PA
    elav-PB
    elav-PC
    elav-PD
    embryonic lethal abnormal visual system
    embryonic lethal, abnormal vision
    embryonically lethal abnormal vision
    weniger

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      509235..523226 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258518.3 → NP_001245447.1  embryonic lethal abnormal vision, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245447.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P16914, Q7K7L9, Q9V3F6
      UniProtKB/TrEMBL
      M9NFP7
      Conserved Domains (1) summary
      TIGR01661
      Location:146 → 483
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    2. NM_001014713.4 → NP_001014713.1  embryonic lethal abnormal vision, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014713.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P16914
      Conserved Domains (1) summary
      TIGR01661
      Location:142 → 479
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    3. NM_001144670.2 → NP_001138142.1  embryonic lethal abnormal vision, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138142.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P16914
      Conserved Domains (1) summary
      TIGR01661
      Location:142 → 479
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    4. NM_080294.5 → NP_525033.1  embryonic lethal abnormal vision, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525033.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P16914, Q7K7L9, Q9V3F6
      UniProtKB/TrEMBL
      M9NFP7
      Related
      FBpp0070086
      Conserved Domains (1) summary
      TIGR01661
      Location:146 → 483
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NFP7 M9NFP7
    P16914.1 P16914

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